The mode of action of sugammadex on coagulation
| Autor: | Ria H. Laterveer, Annelieke C. Kruithof, Cornelis Kluft, Matthijs Moerland, Pieter-Jan de Kam, Jacobus Burggraaf |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Prothrombin time medicine.diagnostic_test Chemistry Activator (genetics) Factor X Sugammadex chemistry.chemical_compound Clotting time Coagulation Factor Xa medicine Humans Partial Thromboplastin Time Pharmacology (medical) Blood Coagulation Tests Blood Coagulation medicine.drug Partial thromboplastin time Blood coagulation test |
| Zdroj: | Int. Journal of Clinical Pharmacology and Therapeutics. 59:89-98 |
| ISSN: | 0946-1965 |
| DOI: | 10.5414/cp203858 |
| Popis: | Objective To explore the mode of action (MoA) by which sugammadex interferes with coagulation. Materials and methods The effect of sugammadex on various steps in the coagulation cascade including thrombin generation, factor Xa activity, and factor Xa generation was explored in human plasma. Results Sugammadex did not affect a conventional thrombin generation test (TGT), while it prolongs activated partial thromboplastin time (APTT) and prothrombin time (PT). However, a customized TGT with PT reagent revealed sugammadex effects. In addition, sugammadex prolonged a one-step prothrombinase-induced clotting time (PiCT) using human factor Xa. Furthermore, sugammadex interfered with factor Xa generation induced by an intrinsic and not by an extrinsic activator, nor by Russell's viper venom factor X (RVV-X). Conclusion Adapted, rather than standard, experiments show that sugammadex is likely to decrease factor Xa activity in the common pathway and activation of factor X specifically in the intrinsic pathway. |
| Databáze: | OpenAIRE |
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