Bone Marrow Monocytes and Derived Dendritic Cells from Myelodysplastic Patients Have Functional Abnormalities Associated with Defective Response to Bacterial Infection
| Autor: | Nydia Strachman Bacal, Laiz Cameirão Bento, Fernanda Agostini Rocha, Luciana Cavalheiro Marti, Patrícia Severino |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
CD86
business.industry T cell Myelodysplastic syndromes Immunology Hematopoietic stem cell Myeloid leukemia chemical and pharmacologic phenomena Dendritic cell Bacterial Infections Dendritic Cells medicine.disease CD56 Antigen Monocytes medicine.anatomical_structure Immune system Bone Marrow hemic and lymphatic diseases Myelodysplastic Syndromes medicine Immunology and Allergy Humans Bone marrow business |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 204(8) |
| ISSN: | 1550-6606 |
| Popis: | Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell diseases characterized by dysplasia of one or more hematologic lineages and a high risk of developing into acute myeloid leukemia. MDS patients have recurrent bacterial infections and abnormal expression of CD56 by monocytes. We investigated MDS patients’ bone marrow CD56+/CD56− monocytes and their in vitro–derived dendritic cell populations in comparison with cells obtained from disease-free subjects. We found that monocytes from MDS patients, irrespective of CD56 expression, have reduced phagocytosis activity and low expression of genes involved in triggering immune responses, regulation of immune and inflammatory response signaling pathways, and in the response to LPS. Dendritic cells derived in vitro from MDS monocytes failed to develop dendritic projections and had reduced expression of HLA-DR and CD86, suggesting that Ag processing and T cell activation capabilities are impaired. In conclusion, we identified, in both CD56+ and CD56− monocytes from MDS patients, several abnormalities that may be related to the increased susceptibility to infections observed in these patients. |
| Databáze: | OpenAIRE |
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