Mature Results of the Ottawa Phase II Study of Intermittent Androgen-Suppression Therapy in Prostate Cancer: Clinical Predictors of Outcome
| Autor: | Libni Eapen, Roanne J. Segal, Juanita Crook, G. Perry, Johanna N. Spaans, Simone Dahrouge, Shawn Malone, Victor Gallant |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Phases of clinical research Androgen suppression Risk Assessment Prostate cancer Clinical Trials Phase II as Topic Risk Factors Prostate Internal medicine Outcome Assessment Health Care Prevalence Humans Medicine Radiology Nuclear Medicine and imaging Survival rate Survival analysis Aged Aged 80 and over Ontario Radiation business.industry Proportional hazards model Prostatic Neoplasms Androgen Antagonists Middle Aged Prostate-Specific Antigen Prognosis medicine.disease Survival Analysis Surgery Survival Rate Clinical trial Treatment Outcome medicine.anatomical_structure Neoplasm Recurrence Local business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 68:699-706 |
| ISSN: | 0360-3016 |
| Popis: | Purpose: To present the mature experience of a phase II trial of intermittent androgen suppression (IAS). Methods and Materials: Intermittent androgen-suppression therapy was initiated in prostate-cancer patients to delay hormone resistance and minimize potential side effects of androgen-deprivation therapy (ADT). Patients received cyclical periods of ADT and observation (off-treatment interval [OTI]). Androgen-deprivation therapy was reinitiated when the level of prostate-specific antigen (PSA) rose above 10 ng/ml, or for disease progression. Associations between clinical factors and eligibility for OTI were measured. Kaplan-Meier and Cox regression analyses were used to determine factors predicting the duration of OTIs. Results: Ninety-five patients completed 187 cycles of treatment. The median duration of OTIs was 8.5 months. Patients with higher PSA and metastatic disease were less likely to be eligible for the first OTI (p < 0.01). In multivariate analysis, patients with higher PSA and local relapse had significantly longer OTIs (p < 0.01) compared with metastatic patients. The median time to withdrawal from the study was 37 months. Conclusions: Intermittent androgen suppression appears to be a favorable treatment option for patients with biochemically (according to level of PSA) or locally recurrent prostate cancer with favorable long-term survival, a high probability of eligibility for OTIs, andmore » durable OTIs.« less |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|