Clinicopathologic characteristics, pathology, and prognosis of 77 dogs with focal segmental glomerulosclerosis

Autor: Rachel E. Cianciolo, Jessica M Quimby, Jessica A. Hokamp, Sarah K. Lorbach
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
podocyte
Biopsy
glomerular disease
Standard Article
030204 cardiovascular system & hematology
Kidney
urologic and male genital diseases
Gastroenterology
0403 veterinary science
chemistry.chemical_compound
0302 clinical medicine
Focal segmental glomerulosclerosis
Medicine
Nephrology/Urology
Hypoalbuminemia
Dog Diseases
lcsh:Veterinary medicine
Proteinuria
medicine.diagnostic_test
Glomerulosclerosis
Focal Segmental
04 agricultural and veterinary sciences
Prognosis
Standard Articles
Renal pathology
protein losing nephropathy
Female
Kidney Diseases
Azotemia
Renal biopsy
medicine.symptom
global glomerulosclerosis
nonimmune complex glomerulopathy
medicine.medical_specialty
040301 veterinary sciences
03 medical and health sciences
Dogs
renal biopsy
Internal medicine
Animals
Retrospective Studies
Creatinine
General Veterinary
business.industry
medicine.disease
chemistry
lcsh:SF600-1100
SMALL ANIMAL
proteinuria
business
Zdroj: Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine, Vol 34, Iss 5, Pp 1948-1956 (2020)
ISSN: 1939-1676
0891-6640
Popis: Background Focal segmental glomerulosclerosis (FSGS) is a common cause of nonimmune complex glomerulopathy and the prognosis and clinicopathologic findings associated with this condition have not been described in dogs. Objective To characterize the presentation and identify clinical factors associated with the survival of dogs with FSGS. Animals Seventy‐seven dogs diagnosed with FSGS based on evaluation of renal biopsy samples submitted to the International Veterinary Renal Pathology Service. Methods Retrospective review of medical records of dogs biopsied for evaluation of proteinuria between January 2015 and May 2017. Results The incidence of FSGS among all dogs biopsied for proteinuria was 26%. Significantly more females (48; 62.3%) than males (29; 37.7%) were affected (P = .04). At the time of biopsy, median serum creatinine concentration (SCr) was 1.2 mg/dL (range, 0.3‐8.7), median serum albumin concentration (Alb) was 2.8 g/dL (range, 1.1‐4.6), median systolic blood pressure was 153.5 mm Hg (range, 95‐260), and median urine protein : creatinine ratio was 5.9 (range, 1.4‐22). Median survival time after biopsy was 258 days (range, 26‐1003) for dogs that died from all causes (n = 32). Factors that were associated with a shorter survival time included SCr ≥ 2.1 mg/dL (P
Databáze: OpenAIRE
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