Influence of age on histologic outcome of cervical intraepithelial neoplasia during observational management: results from large cohort, systematic review, meta-analysis
| Autor: | Reinhard Horvat, Georg Heinze, Mariella Polterauer, Christine Bekos, Richard Schwameis, Stephan Polterauer, Christoph Grimm, Marina Gärner, Elmar A. Joura |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Multivariate analysis Biopsy Uterine Cervical Neoplasms lcsh:Medicine Cervical intraepithelial neoplasia Article 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans lcsh:Science Retrospective Studies Colposcopy 030219 obstetrics & reproductive medicine Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Age Factors Disease Management Retrospective cohort study Prognosis Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications Natural history Observational Studies as Topic 030220 oncology & carcinogenesis Meta-analysis Disease Progression Female lcsh:Q Observational study business |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Aim of this study was to investigate the histologic outcome of cervical intraepithelial neoplasia (CIN) during observational management. Consecutive women with histologically verified CIN and observational management were included. Histologic findings of initial and follow-up visits were collected and persistence, progression and regression rates at end of observational period were assessed. Uni- and multivariate analyses were performed. A systematic review of the literature and meta-analysis was performed. In 783 women CIN I, II, and III was diagnosed by colposcopically guided biopsy in 42.5%, 26.6% and 30.9%, respectively. Younger patients had higher rates of regression (p 40 years, regression rates were 44.7%, 33.7%, 30.9%, 27.3%, and 24.9%, respectively. Pooled analysis of published data showed similar results. Multivariable analysis showed that with each five years of age, the odds for regression reduced by 21% (p |
| Databáze: | OpenAIRE |
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