Evaluation of electrospun PLLA/PEGDMA polymer coatings for vascular stent material

Autor: Naveen Nagiah, Wei Tan, Parnaz Boodagh, Dong-Jie Guo
Rok vydání: 2016
Předmět:
Blood Platelets
Materials science
Cell Survival
Surface Properties
medicine.medical_treatment
Polyesters
Myocytes
Smooth Muscle
Biomedical Engineering
Biophysics
Nanofibers
Bioengineering
02 engineering and technology
030204 cardiovascular system & hematology
engineering.material
Pulmonary Artery
Polyethylene Glycols
Biomaterials
03 medical and health sciences
0302 clinical medicine
Restenosis
Coating
Coated Materials
Biocompatible
medicine
Alloys
Cell Adhesion
Animals
Humans
Composite material
Blood coagulation test
Cell Proliferation
Mesenchymal stem cell
Stent
Endothelial Cells
021001 nanoscience & nanotechnology
medicine.disease
Electrospinning
Elasticity
Rats
Polyester
Nanofiber
engineering
Methacrylates
Stents
Blood Coagulation Tests
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Biomedical engineering
Zdroj: Journal of biomaterials science. Polymer edition. 27(11)
ISSN: 1568-5624
Popis: The field of percutaneous coronary intervention has seen a plethora of advances over the past few decades, which have allowed for its development into safe and effective treatments for patients suffering from cardiovascular diseases. However, stent thrombosis and in-stent restenosis remain clinically significant problems. Herein, we describe the synthesis and characterization of fibrous polymer coatings on stent material nitinol, in the hopes of developing a more suitable stent surface to enhance re-endothelialization. Electrospinning technique was used to fabricate polyethylene glycol dimethacrylate/poly l-lactide acid (PEGDMA/PLLA) blend fiber substrate with tunable elasticity and hydrophilicity for use as coatings. Attachment of platelets and arterial smooth muscle cells (SMC) onto the coatings as well as the secretory effect of mesenchymal stem cells cultured on the coatings on the proliferation and migration of arterial endothelial cells and SMCs were assessed. It was demonstrated that electrospun PEGDMA/PLLA coating with 1:1 ratio of the components on the nitinol stent-reduced platelet and SMC attachment and increased stem cell secretory factors that enhance endothelial proliferation. We therefore postulate that the fibrous coating surface would possess enhanced biological compatibility of nitinol stents and hold the potential in preventing stent failure through restenosis and thrombosis.
Databáze: OpenAIRE
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