Survival of large bowel carcinoma patients with different DNA ploidy
| Autor: | Eiliv Lund, Torleiv O. Rognum, E. Thorud |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Time Factors Rectum Large Bowel Carcinoma Biology Left colon medicine Humans Stage (cooking) Dna ploidy Aged Neoplasm Staging Aged 80 and over Ploidies Rectal Neoplasms Follow up studies DNA Neoplasm Middle Aged Flow Cytometry Prognosis Diploidy medicine.anatomical_structure Oncology Colonic Neoplasms Female Neoplasm staging Ploidy Follow-Up Studies Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1987.257 |
| Popis: | One hundred patients operated for large bowel carcinoma were divided into a distinct aneuploid group of 63, and a near diploid one of 37. Flow cytometry was used for determination of the DNA ploidy pattern. All tumours in the aneuploid group contained one or more aneuploid cell populations. All patients were followed clinically from 3.5 to 7.8 years. The corrected 5 year survival was 64% and 49% for patients with near diploid and aneuploid tumours, respectively (not significant). Significant differences in corrected survival time were not observed for Dukes' stages A, B, and C patients pooled, nor for Dukes' stage D patients. However, for Dukes' stage C patients alone, there was a tendency (P = 0.10) for patients with near diploid tumours to show a better survival. A highly significant predominance of aneuploid tumours was seen in males, in contrast to an equal distribution of aneuploid and near diploid tumours in females. A slight predominance of aneuploid tumours in the left colon and rectum was seen. Both these findings indicate the influence of environmental factors (hormonal, anatomical, phenotypical) on the development of tumours with a particular DNA ploidy pattern. |
| Databáze: | OpenAIRE |
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