Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug–Drug Interaction Risk Profile

Autor:	Junliang Hao, James Beck, Xin Zhou, Gregory L. Lackner, Richard Johnston, Matt Reinhard, Paul Goldsmith, Sean Hollinshead, Veronique Dehlinger, Sandra A. Filla, Xu-shan Wang, Jeffery Richardson, Maria Posada, Mike Mohutsky, Doug Schober, Jason S. Katner, Qi Chen, Bingjie Hu, David M. Remick, David A. Coates, Brian M. Mathes, Mai K. Hawk, Kjell A. Svensson, Erik Hembre
Rok vydání:	2022
Předmět:	Neuroprotective Agents Allosteric Regulation Receptors Dopamine D1 Drug Discovery Cytochrome P-450 CYP3A Cytochrome P-450 CYP3A Inhibitors Humans Molecular Medicine Drug Interactions
Zdroj:	Journal of Medicinal Chemistry. 65:3786-3797
ISSN:	1520-4804 0022-2623
DOI:	10.1021/acs.jmedchem.1c01887
Popis:	Results from recently completed clinical studies suggest the dopamine D1 receptor positive allosteric modulator (PAM) mevidalen (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49a9e53e8ff14e333d25d7a619375ea https://doi.org/10.1021/acs.jmedchem.1c01887 Zobrazit plný text záznamu