HLA polymorphism in three indigenous populations of Sabah and Sarawak
| Autor: | Y. A. Irda, Y. Y. Lee, A. Azrena, M. Salawati, M. Shahnaz, C. L. Too, J. S. Dhaliwal |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Immunology
Human leukocyte antigen Biology Biochemistry Asian People Population Groups HLA Antigens Polymorphism (computer science) Genetics Humans Immunology and Allergy Allele Alleles Polymorphism Genetic HLA-A Antigens HLA-B40 Antigen Histocompatibility Antigens Class I Haplotype Histocompatibility Antigens Class II Malaysia HLA-DR Antigens General Medicine Haplotypes HLA-B Antigens HLA-DRB1 Chains |
| Zdroj: | Tissue Antigens. 75:166-169 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | One hundred and fifty-eight Kadazan, Iban and Bidayuh individuals registered with the Malaysian Marrow Donor Registry were typed for human leukocyte antigen (HLA)-A, HLA-B and HLA-DR. Six, seven and eight HLA-A alleles as well as 13, 15 and 16 HLA-B alleles were detected in the Kadazan, Bidayuh and Iban, respectively. The most common HLA-A allele in all three groups was HLA-A*24 with a frequency of 0.456, 0.490 and 0.422 in the Kadazan, Bidayuh and Iban, respectively. The most common HLA-B allele detected in the Kadazan was HLA-B*40 with a frequency of 0.333; for the Bidayuh and the Iban it was HLA-B*15 with a frequency of 0.460 and 0.275, respectively. The HLA-DR allele with the highest frequency in the Kadazan was HLA-DR*1502 with a frequency of 0.500. In the Iban and the Bidayuh, HLA-DRB1*1202 was the most common DR allele with frequencies of 0.235 and 0.310, respectively. The two most common haplotypes for the Kadazan are A*34-B*38-DR*1502 and A*24-B*40-DR*0405, whereas for the Bidayuh they are A*24-B*15-DR*1602 and A*24-B*35-DR*1202 and for the Iban they are A*34-*B15-DR*1502 and A*24-B*15-DR*1202. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|