Cranberry (Vaccinium macrocarpon) peel polyphenol-rich extract attenuates rat liver mitochondria impairments in alcoholic steatohepatitis in vivo and after oxidative treatment in vitro
| Autor: | Grażyna Budryn, Siarhei Kirko, T. V. Ilyich, Dorota Zyzelevicz, Lyudmila Kiryukhina, Agnieszka Zakrzeska, Vyacheslav Buko, Oxana Lukivskaya, Joanna Orach, Elena A. Lapshina, Elena Naruta, Elena Belonovskaya, Irina Kuzmitskaya, Ilya B. Zavodnik |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Medicine (miscellaneous) Oxidative phosphorylation Cranberry peel polyphenols Mitochondrion Pharmacology 03 medical and health sciences 0404 agricultural biotechnology Flavonols In vivo medicine TX341-641 chemistry.chemical_classification Mitochondrial permeability transition 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply food and beverages 04 agricultural and veterinary sciences medicine.disease 040401 food science Alcoholic steatohepatitis chemistry Mitochondrial permeability transition pore Liver Polyphenol Steatosis Mitochondrial ultrastructure Food Science |
| Zdroj: | Journal of Functional Foods, Vol 57, Iss, Pp 83-94 (2019) |
| ISSN: | 1756-4646 |
| Popis: | Alcoholic steatohepatitis is an important medical problem but its effective therapies are still not available. Plant polyphenols are widely used for prevention of toxic liver damages. The aim of the study was to evaluate the hepatoprotective mechanism(s) of a cranberry peel polyphenol-rich extract, focusing on the effects of the polyphenols on the mitochondrial function. The main components of cranberry peel phenolic compounds were anthocyanins, flavan-3-ols, procyanidins, flavonols, phenolic acids, as was detected using UHPLC-ESI-QTOF-MS. The treatment of rats receiving ethanol (4 g/kg bw, 8 weeks) with cranberry polyphenols (daily, 4 mg/kg bw) partially prevented alcoholic liver damage, ameliorating steatosis and inflammatory signs in the liver, decreasing serum and liver triglyceride contents, ALT and AST activities, as well as diminishing TNFα and TGFβ levels in serum. The polyphenols inhibited Ca2+ - induced mitochondrial permeability transition, free radical generation in mitochondria during intoxication. The polyphenols (25 µg/ml) prevented mitochondrial oxidative impairments in vitro. In conclusion, the cranberry peel polyphenols with antioxidant properties exerted a hepatoprotective and anti-inflammatory effects in the model of alcoholic steatohepatitis via prevention of liver mitochondria dysfunction. |
| Databáze: | OpenAIRE |
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