Is there a role of toothpastes in the development of recurrent aphthous stomatitis? A prospective controlled clinical trial with skin patch testing
| Autor: | Hatice Kaya Ozden, Ayse Adin Selcuk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.product_category Cocamidopropyl betaine Recurrent aphthous stomatitis Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Prospective Studies Oral mucosa Stomatitis Toothpaste business.industry Patch test Sodium Dodecyl Sulfate 030206 dentistry Patch Tests medicine.disease Dermatology Skin patch Exact test medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Surgery Stomatitis Aphthous Oral Surgery business Toothpastes |
| Zdroj: | Oral surgery, oral medicine, oral pathology and oral radiology. 131(1) |
| ISSN: | 2212-4411 |
| Popis: | The oral mucosa is exposed to a large number of antigenic agents contained in toothpastes. These agents are reported to stimulate recurrent aphthous stomatitis (RAS) pathogenesis, and toothpastes that do not contain probable allergenic substances reduced the number and frequency of aphthous ulcers. We aimed to determine whether the skin patch test (SPT) can be used to determine if toothpaste allergens play a role in the etiology of RAS.Sixty-three patients with RAS and 47 healthy volunteers were skin patch tested with sodium lauryl sulfate, cocamidopropyl betaine, propylene glycol, aluminum chloride hexahydrate, menthol, triclosan, and titanium dioxide, which are present in most of the toothpastes. Fisher's exact test and the Yates chi-square test were used to compare categorical variables and patch test results between 2 groups.The SPT was positive in 8 (22.2%) patients with RAS and 11 (23.4%) control subjects, and the difference between the groups was not statistically significant (P.05). Sodium lauryl sulfate, titanium dioxide, and menthol were the most common positive allergens in both groups.Allergens in toothpastes did not appear to stimulate the formation of RAS. However, in order to determine a clearer relationship, a study in a larger patient series employing intraoral patch testing with more toothpaste ingredients is suggested. |
| Databáze: | OpenAIRE |
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