Reference materials and representative test materials to develop nanoparticle characterization methods: the NanoChOp project case
| Autor: | Christian Gollwitzer, Dorota Bartczak, Daniel Geißler, James E. Noble, Judith Mihály, Julie Davies, Ute Resch-Genger, Marcell Pálmai, Aneta Sikora, Heidi Goenaga-Infante, Nele Meeus, Neelam Kumarswami, Yannic Ramaye, Zoltán Varga, Gert Roebben, Caterina Minelli, Vikram Kestens, Michael Krumrey, Philippe Corbisier, Jean Charoud-Got, Stéphane Mazoua |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Analytical quality assurance
Nanoparticle Characterization Chemistry Materials characterization nanoparticle Nanoparticle Nanotechnology General Chemistry Metrology Nanomaterials lcsh:Chemistry Dynamic light scattering lcsh:QD1-999 Attenuated total reflection Zeta potential Surface modification Particle size Reference material Technology Report |
| Zdroj: | Frontiers in Chemistry, Vol 3 (2015) Frontiers in Chemistry |
| ISSN: | 2296-2646 |
| Popis: | This paper describes the production and characteristics of the nanoparticle test materials prepared for common use in the collaborative research project NanoChOp (Chemical and optical characterisation of nanomaterials in biological systems), in casu suspensions of silica nanoparticles and CdSe/CdS/ZnS quantum dots. This paper is the first to illustrate how to assess whether nanoparticle test materials meet the requirements of a 'reference material' (ISO Guide 30:2015) or rather those of the recently defined category of 'representative test material' (ISO TS 16195:2013). The NanoChOp test materials were investigated with small-angle X-ray scattering (SAXS), dynamic light scattering (DLS) and centrifugal liquid sedimentation (CLS) to establish whether they complied with the required monomodal particle size distribution. The presence of impurities, aggregates, agglomerates and viable microorganisms in the suspensions was investigated with DLS, CLS, optical and electron microscopy and via plating on nutrient agar. Suitability of surface functionalization was investigated with attenuated total reflection Fourier transform infrared spectrometry (ATR-FTIR) and via the capacity of the nanoparticles to be fluorescently labeled or to bind antibodies. Between-unit homogeneity and stability were investigated in terms of particle size and zeta potential. This paper shows that only based on the outcome of a detailed characterization process one can raise the status of a test material to representative test material or reference material, and how this status depends on its intended use. |
| Databáze: | OpenAIRE |
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