Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation inalpha2‐macroglobulinandtau: A population‐based autopsy study
| Autor: | Pentti J. Tienari, Liisa Myllykangas, Raimo Sulkava, Irma-Leena Notkola, Andrew B. Singleton, Sari Kiuru-Enari, Terhi Peuralinna, Tuomo Polvikoski, Anders Paetau, Maarit Tanskanen, John Hardy |
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| Rok vydání: | 2008 |
| Předmět: |
Male
musculoskeletal diseases Pathology medicine.medical_specialty Population Myocardial Infarction tau Proteins 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Gene Frequency stomatognathic system Risk Factors Genotype Prevalence medicine Humans Prealbumin alpha-Macroglobulins education Allele frequency Finland Aged 80 and over education.field_of_study Polymorphism Genetic biology business.industry Myocardium Amyloidosis Haplotype Age Factors Congo Red Exons General Medicine medicine.disease Immunohistochemistry eye diseases 3. Good health Genotype frequency stomatognathic diseases Transthyretin Haplotypes biology.protein Female Autopsy Amyloid cardiomyopathy business 030217 neurology & neurosurgery |
| Zdroj: | Annals of Medicine. 40:232-239 |
| ISSN: | 1365-2060 0785-3890 |
| DOI: | 10.1080/07853890701842988 |
| Popis: | Senile systemic amyloidosis (SSA) is characterized by deposition of wild-type transthyretin (TTR)-based amyloid in parenchymal organs in elderly individuals. Previously, no population-based studies have been performed on SSA.Here we have studied the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over, as part of the population-based Vantaa 85+ Autopsy Study (n = 256). The diagnosis of SSA was based on histological examination of myocardial samples stained with Congo red and anti-TTR immunohistochemistry. The genotype frequencies of 20 polymorphisms in 9 genes in subjects with and without SSA were compared.The prevalence of SSA was 25%. SSA was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (alpha2M), and the H2 haplotype of the tau gene (P-values 0.002, 0.004, 0.042, and 0.016).This population-based study shows that SSA is very common in old individuals, affecting one-quarter of people aged over 85 years. Myocardial infarctions and variation in the genes for alpha2M and tau may be associated with SSA. |
| Databáze: | OpenAIRE |
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