Effects of Isoprinosine on Echinococcus multilocularis and E. granulosus metacestodes
| Autor: | A F Petavy, Marie-Elisabeth Sarciron, S. Walbaum |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cestoda Helminthiasis Mice Inbred Strains Echinococcus multilocularis Mice In vivo Echinococcosis Inosine Pranobex parasitic diseases medicine Parasite hosting Animals Anthelmintic Echinococcus granulosus Abdominal Muscles General Veterinary biology Dose-Response Relationship Drug Cysts General Medicine biology.organism_classification medicine.disease Echinococcus Infectious Diseases Insect Science Ultrastructure Parasitology Female Gerbillinae medicine.drug |
| Zdroj: | Parasitology research. 81(4) |
| ISSN: | 0932-0113 |
| Popis: | An in vivo study of the effect of Isoprinosine on Echinococcus multilocularis and E. granulosus metacestodes (Cestoda) was performed. Short- and long-term treatments with different doses were tested in experimental hosts: jirds for E. multilocularis and mice for E. granulosus. Modifications in the weight of animals as well as macroscopical and ultrastructural aspects were registered for each animal group. The results obtained showed a considerable ultrastructural alteration in E. multilocularis metacestodes after short-term treatment with the highest dose, and the tissue transplants were negative. In E. granulosus cysts the ultrastructural damage was also very important and its severity increased as the dose was raised. For the two parasites, the macroscopical aspect and weight of the lesions were profoundly changed. |
| Databáze: | OpenAIRE |
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