Anxiety in Late-Life Depression: Determinants of the Course of Anxiety and Complete Remission
| Autor: | Hannie C. Comijs, Sebastian Köhler, Robert A. Schoevers, Date C. van der Veen, Willeke H. van Zelst, Bernice Gulpers, Richard C. Oude Voshaar |
|---|---|
| Přispěvatelé: | Clinical Cognitive Neuropsychiatry Research Program (CCNP), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
media_common.quotation_subject Comorbidity Anxiety Life Change Events late-life depression 03 medical and health sciences 0302 clinical medicine medicine Humans Personality Big Five personality traits Depression (differential diagnoses) Aged Netherlands media_common Aged 80 and over Neuroticism Depressive Disorder Major 030214 geriatrics business.industry Comorbid anxiety Remission Induction Middle Aged Late life depression Prognosis medicine.disease Anxiety Disorders negative life events Psychiatry and Mental health personality Major depressive disorder Female Observational study Self Report Geriatrics and Gerontology medicine.symptom business Clinical psychology |
| Zdroj: | American Journal of Geriatric Psychiatry, 29(4), 336-347. ELSEVIER SCIENCE INC American Journal of Geriatric Psychiatry, 29(4), 336-347. Elsevier Science |
| ISSN: | 1064-7481 |
| DOI: | 10.1016/j.jagp.2020.12.023 |
| Popis: | OBJECTIVE: Studies on the course of depression often ignore comorbid anxiety disorders or anxiety symptoms. We explored predictors of complete remission (no depression nor anxiety diagnoses at follow-up) and of the course of comorbid anxiety symptoms. We additionally tested the hypothesis that the course of anxiety disorders and symptoms in depressed patients is explained by negative life-events in the presence of high neuroticism or a low sense of mastery.METHODS: An observational study of 270 patients (≥60 years) diagnosed with major depressive disorder and 2-year follow-up data, who participated in the Netherlands Study of Depression in Older persons (NESDO). Sociodemographic, somatic, psychiatric, and treatment variables were first explored as possible predictors. A multiple logistic regression analysis was used to examine their predictive value concerning complete remission. Subsequently, negative life-events, personality and their interaction were tested as potential predictors. Linear Mixed Models were used to assess whether the personality traits modified the effect of early and recent life-events, and time and their interactions on the course of the anxiety symptoms.RESULTS: A total of 135 of 270 patients achieved complete remission. Depressed patients with a comorbid anxiety disorder at baseline less often achieved complete remission: 38 of 103 (37.0%) versus 97 of 167 (58.1%). The severity of depressive and anxiety symptomatology, the presence of a comorbid anxiety disorder, and a poorer physical health at baseline predicted nonremission. In line with our hypothesis, a less favorable course of self-reported anxiety symptoms was associated with more recent negative life-events, but only among patients with a high level of neuroticism or a low level of mastery.CONCLUSION: Comorbid anxiety in depression as a negative impact on complete remission at 2-year follow-up. The course of anxiety severity seems dependent on the interaction of personality traits and life-events. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|