Toward a Total Synthesis of the Novel Polyketide Natural Product Spiculoic Acid A
| Autor: | U. K. Kundu, Goverdhan Mehta |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Biological Products
Natural product Molecular Structure Bicyclic molecule Stereochemistry Organic Chemistry Carboxylic Acids Enantioselective synthesis Total synthesis Stereoisomerism General Medicine Biochemistry Combinatorial chemistry Porifera chemistry.chemical_compound Polyketide chemistry Intramolecular force Core (graph theory) Indans Animals Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 7:5569-5572 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol0521329 |
| Popis: | [chemical reaction: see text]. An enantioselective approach toward the recently isolated marine natural product, spiculoic acid A, conceptualized along the proposed biogenetic hypothesis, involving an intramolecular Diels-Alder reaction as the pivotal step, is delineated. Access to a structurally embellished bicyclic core of the natural product has been accomplished. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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