Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response

Autor: Xiao-Hua Yu, Qi-Xian Liu, Meng-Wen Shi, Wen-Yi Deng, Kun Ren, Xiao-Dan Xu, Jiao-Jiao Chen
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Apolipoprotein E
Aging
Mice
Knockout
ApoE
THP-1 Cells
030204 cardiovascular system & hematology
Pharmacology
Biochemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
skin and connective tissue diseases
ATP Binding Cassette Transporter
Subfamily G
Member 1
Liver X Receptors
biology
Chemistry
Reverse cholesterol transport
General Medicine
Genistein
Lipids
Cholesterol
ABCG1
Cytokines
lipids (amino acids
peptides
and proteins)
Research Article
ATP Binding Cassette Transporter 1
Signal Transduction
Article Subject
Brassica
Protective Agents
Biochanin A
Proinflammatory cytokine
03 medical and health sciences
Animals
Humans
Liver X receptor
Inflammation
QH573-671
Plant Extracts
Cell Biology
Atherosclerosis
Lipid Metabolism
PPAR gamma
Heme oxygenase
Disease Models
Animal
030104 developmental biology
Diet
Western
ABCA1
biology.protein
Trifolium
Cytology
Heme Oxygenase-1
Foam Cells
Phytotherapy
Zdroj: Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity
ISSN: 1942-0994
1942-0900
Popis: Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury. However, very little is known about its role in atherogenesis. The aim of this study was to observe the effects of BCA on atherosclerosis and explore the underlying mechanisms. Our results showed that administration of BCA promoted reverse cholesterol transport (RCT), improved plasma lipid profile, and decreased serum proinflammatory cytokine levels and atherosclerotic lesion area in apoE-/- mice fed a Western diet. In THP-1 macrophage-derived foam cells, treatment with BCA upregulated ATP-binding cassette (ABC) transporter A1 (ABCA1) and ABCG1 expression and facilitated subsequent cholesterol efflux and diminished intracellular cholesterol contents by activating the peroxisome proliferator-activated receptor γ (PPARγ)/liver X receptor α (LXRα) and PPARγ/heme oxygenase 1 (HO-1) pathways. BCA also activated these two signaling pathways to inhibit the secretion of proinflammatory cytokines. Taken together, these findings suggest that BCA is protective against atherosclerosis by inhibiting lipid accumulation and inflammatory response through the PPARγ/LXRα and PPARγ/HO-1 pathways. BCA may be an attractive drug for the prevention and treatment of atherosclerotic cardiovascular disease.
Databáze: OpenAIRE
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