Activity of BMS-284756, a Novel Des-Fluoro(6) Quinolone, against Staphylococcus aureus , Including Contributions of Mutations to Quinolone Resistance

Autor:	Matthew P. Muller, Donald E. Low, Barry N. Kreiswirth, D. J. Bast, J.C.S. De Azavedo, Sylvia Pong-Porter, Allison McGeer, Carla Duncan, Barbara M. Willey
Rok vydání:	2002
Předmět:	DNA Topoisomerase IV DNA Bacterial Staphylococcus aureus Indoles Meticillin medicine.drug_class Antibiotics Microbial Sensitivity Tests Quinolones Biology Staphylococcal infections medicine.disease_cause Microbiology Minimum inhibitory concentration Anti-Infective Agents medicine Humans Topoisomerase II Inhibitors Pharmacology (medical) Antibacterial agent Pharmacology Drug Resistance Microbial Staphylococcal Infections Quinolone medicine.disease Ciprofloxacin Infectious Diseases Amino Acid Substitution Susceptibility DNA Gyrase Mutation Methicillin Resistance Fluoroquinolones medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy. 46:1119-1121
ISSN:	1098-6596 0066-4804
Popis:	The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC ≥4 μg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 μg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 μg/ml, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48bea2c6c9b53cfac715b044e17f5b0 https://doi.org/10.1128/aac.46.4.1119-1121.2002 Zobrazit plný text záznamu