Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis
| Autor: | Wenjie Sui, Haifang Wang, Lan Xu, Mei'e Niu, Lei Ding, Rulan Yin, Mingjun Wang, Rong Xu, Chomphoonut Srirat |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Subgroup analysis Review Article Cochrane Library Gastroenterology General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Lupus Erythematosus Systemic Medicine skin and connective tissue diseases 030203 arthritis & rheumatology General Immunology and Microbiology business.industry Interleukin-17 General Medicine Publication bias Middle Aged Confidence interval 030104 developmental biology Strictly standardized mean difference Meta-analysis Biomarker (medicine) Female Interleukin 17 business Publication Bias |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2021 (2021) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2021/9952463 |
| Popis: | Previous studies on the relationship between the circulating level of interleukin-17 (IL-17) and disease activity in systemic lupus erythematosus (SLE) were contradictory. This study is aimed at quantitatively assessing the correlation between the circulating IL-17 level and disease activity in SLE patients. A systematic search for related literature was conducted via PubMed, Web of Science, EMBASE, and Cochrane Library (up to January 26, 2021). The relationship between circulating IL-17 levels and SLE activity was evaluated using Fisher’szvalue, which was then converted tor. The standardized mean difference (SMD) and its 95% confidence interval (CI) were used to describe the difference between the circulating IL-17 level in patients with active and inactive SLE. STATA 16.0 was used to perform statistical analysis. Random-effects model was performed to synthesize data. Twenty-six studies involving 1,560 SLE patients were included in this review. The pooledrvalue was 0.38 (95% CI: 0.25-0.50;I2=83.8%,P<0.001) between the SLE activity and circulating level of IL-17. Patients with active SLE had higher level of circulating IL-17 than that of inactive (pooled SMD=0.95, 95% CI: 0.38-1.53;I2=90.5%,P<0.001). The subgroup analysis suggested that the region and detection method of circulating IL-17 might not be a source of heterogeneity. No significant publication bias was found. In summary, circulating IL-17 level has a low positive relationship with SLE activity. It is necessary to carefully consider the use of circulating IL-17 as a biomarker of the disease activity in SLE patients. The relationship between the circulating level of IL-17 and SLE activity should be further confirmed in randomized controlled studies. |
| Databáze: | OpenAIRE |
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