A Reciprocating, Single-Needle Hemodialyzer with Bidirectional Flow of Sorbent Suspension
| Autor: | Jerry A. Thornhill, David P. Kessler, Fred E. Regnier, Stephen R. Ash, Donald E. Blake, Patrick F. Belcastro, Nien-Hwa L. Wang, Ronald G. Barile, Shri Gupta |
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| Rok vydání: | 2008 |
| Předmět: |
Sorbent
Sodium Bicarbonate Potassium Biomedical Engineering Ultrafiltration Medicine (miscellaneous) chemistry.chemical_element Renal function Bioengineering Absorption Blood Urea Nitrogen Biomaterials chemistry.chemical_compound Dogs Suspensions Renal Dialysis In vivo Animals Creatinine Chromatography Biological Transport Membranes Artificial General Medicine Disease Models Animal chemistry Urea Kidney Failure Chronic Rheology Kidneys Artificial |
| Zdroj: | Artificial Organs. 6:267-279 |
| ISSN: | 1525-1594 0160-564X |
| DOI: | 10.1111/j.1525-1594.1982.tb01672.x |
| Popis: | Previous theoretical analysis has indicated that adequate mass transfer is possible in a dialyzer with reciprocating membrane motion provided that the dialysate concentration of uremic substances is kept low. Earlier models have utilized a collection of sorbents (charcoal, urease, and a cation exchanger) constrained next to the dialyzer membranes. We have designed a new dialyzer with a sorbent suspension having free access from a reservoir to the spaces between membrane packages. At a treatment rate of 150 ml/min/m2, the in vitro creatinine clearance is 75 ml/min/m2, which agrees within experimental accuracy with the theoretical prediction. The creatinine clearance, flow resistance, and compliance of the dialyzer are constant during four to six hours of testing. In vivo tests have been performed during urea and creatinine infusion in a normal dog and in a dog with 3/4 nephrectomy. The in vivo creatinine clearance agrees within 10% with the in vitro clearance. Sodium, potassium, calcium, and bicarbonate fluxes are acceptable for patients in renal failure. The new design allows a higher capacity for urea and creatinine, since larger amounts of sorbent may be used. |
| Databáze: | OpenAIRE |
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