Chemotherapy-colchicine interaction in a child with Familial Mediterranean Fever and Hodgkin Lymphoma
Autor: | L. Lee Dupuis, Yaron Finkelstein, Oussama Abla, Ronald M. Laxer, Angela Punnett, Karin Langenberg-Ververgaert |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Vincristine medicine.medical_treatment Familial Mediterranean fever Case Report Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nodular sclerosis Prednisone Internal medicine medicine Colchicine Doxorubicin Etoposide Colchicine toxicity Chemotherapy business.industry lcsh:RC633-647.5 Hodgkin lymphoma familial Mediterranean fever colchicine Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease 030104 developmental biology Infectious Diseases chemistry 030220 oncology & carcinogenesis business Hodgkin lymphoma Drugs interaction medicine.drug |
Zdroj: | Mediterranean Journal of Hematology and Infectious Diseases, Vol 10, Iss 1, Pp e2018019-e2018019 (2018) Mediterranean Journal of Hematology and Infectious Diseases |
ISSN: | 2035-3006 |
Popis: | Familial Mediterranean fever (FMF) has been associated with hematological malignancies but has not been reported in association with Hodgkin lymphoma (HL). We hereby describe the first pediatric patient with FMF and stage IIA nodular sclerosis HL. She was treated with prednisone, doxorubicin, vincristine and etoposide (OEPA) being on therapy with colchicine. However, she suffered more than expected treatment-related toxicity attributed either to chemotherapy (severe neutropenia) or colchicine (Abdominal pains and diarrhoea). Colchicine had to be discontinued. In the absence of colchicine, she tolerated very well the second cycle of chemotherapy. Currently, she is in remission at 17 months after her HL diagnosis, and her FMF is under control with colchicine without any signs of toxicity. |
Databáze: | OpenAIRE |
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