Sacubitril/valsartan in the treatment of systemic right ventricular failure
| Autor: | Monique R.M. Jongbloed, Berto J. Bouma, Hubert W. Vliegen, Philippine Kiès, Tjitske E Zandstra, Anastasia D Egorova, Martin J. Schalij, Laurens F. Tops, Marieke Nederend |
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| Přispěvatelé: | Cardiology, ACS - Heart failure & arrhythmias, ACS - Pulmonary hypertension & thrombosis |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty complex congenital heart disease heart failure Context (language use) Sacubitril Angiotensin Receptor Antagonists Internal medicine medicine Humans Retrospective Studies transposition of the great arteries Ejection fraction business.industry Aminobutyrates Biphenyl Compounds Middle Aged medicine.disease congenital heart disease Angiotensin II Drug Combinations Treatment Outcome Valsartan Echocardiography Great arteries Heart failure Quality of Life Ventricular Function Right Cardiology Female Cardiology and Cardiovascular Medicine business Sacubitril Valsartan Follow-Up Studies medicine.drug |
| Zdroj: | Heart, 107, 1725-1730. BMJ Publishing Group Heart Heart, 107(21), 1725-1730. BMJ PUBLISHING GROUP |
| ISSN: | 1468-201X 1355-6037 |
| Popis: | ObjectivePharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients.MethodsData on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circulation treated with sacubitril/valsartan in our centre are reported. Patients with a systemic RV ejection fraction of ≤35% who were symptomatic despite treatment with β-blocker and ACE-inhibitor/angiotensin II receptor-blockers were started on sacubitril/valsartan. This cohort underwent structural follow-up including echocardiography, exercise testing, laboratory investigations and quality of life (QOL) assessment.ResultsSix-month follow-up data were available in 18 out of 20 patients, including 12 (67%) patients with TGA after atrial switch and 6 (33%) patients with ccTGA. N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) decreased significantly (950–358 ng/L, pConclusionsWe describe the first patient cohort with systemic RV failure treated with sacubitril/valsartan. Treatment appears feasible with improvements in NT-pro-BNP and echocardiographic function. Our positive results show the potential of sacubitril/valsartan for this patient population. |
| Databáze: | OpenAIRE |
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