Troponin-T: improved diagnostic assessment of myocardial damage in childhood
Autor: | Jean-Pierre Pfammatter, Printzen G, Peheim E, Immer Ff, Franco P. Stocker, Seiler Am |
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Rok vydání: | 1997 |
Předmět: |
Male
medicine.medical_specialty Heart disease Creatine Sensitivity and Specificity chemistry.chemical_compound Troponin T Troponin complex Predictive Value of Tests Internal medicine Preoperative Care medicine Humans Postoperative Period Child Creatine Kinase biology business.industry Infant Newborn Infant General Medicine Prognosis medicine.disease Troponin Surgery Cardiac surgery Isoenzymes chemistry Great vessels Child Preschool Pediatrics Perinatology and Child Health biology.protein Cardiology Female Creatine kinase Cardiomyopathies business Biomarkers |
Zdroj: | Acta Paediatrica. 86:1321-1327 |
ISSN: | 1651-2227 0803-5253 |
Popis: | Troponin-T (cTnT) as a marker of myocardial damage is well established in adults, but not yet in children. cTnT was measured in 85 children (aged 1 day-204 months, mean 46 months). Twenty-five children were non-surgical patients, with possible myocardial damage suspected on clinical grounds. The other 60 patients had cardiac surgery leading to a defined myocardial damage. In these children, troponin-T (cTnT), creatine kinase activity (CK), creatine kinase-MB activity (CK-MB), and creatine kinase-MB-Mass (CK-MB-Mass) were measured preoperatively and 3-4 times during the first 55 postoperative h. Except in four children with probable preoperative myocardial damage, all troponin-T values were in the normal range (< 0.1 microg/l). All children with intracardiac surgery showed a postoperative increase in troponin-T. Children with extracardiac surgery of the great vessels showed no postoperative increase of troponin-T. For the assessment of myocardial damage, troponin-T was more specific and more sensitive than the other markers tested, troponin-T might significantly improve the diagnostic assessment of myocardial damage in children. |
Databáze: | OpenAIRE |
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