Carcinogenicity of N-nitrosobis (2-hydroxypropyl) amine after administration to Syrian hamster skin
| Autor: | Katherine Stepan, Parviz M. Pour |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Cancer Research Nitrosamines Skin Neoplasms Mesocricetus Skin Absorption Hamster Absorption (skin) Pharmacology chemistry.chemical_compound Structure-Activity Relationship Oncology Biochemistry chemistry Nitrosamine Cricetinae Carcinogens Animals Amine gas treating Syrian golden hamsters Respiratory system Human cancer Carcinogen |
| Zdroj: | Cancer letters. 27(3) |
| ISSN: | 0304-3835 |
| Popis: | Weekly application of N-nitrosobis (2-hydroxypropyl) amine (BHP) at a dose of 50 mg/application to the skin of the neck and flank organ of male Syrian golden hamsters induced no local lesions. However, nearly all treated animals developed internal tumors, primarily of pancreatic, hepatic, respiratory and colorectal origins. Results from this and previous studies indicate that the local carcinogenic effect of nitrosamines depends on the molecular structure of the carcinogen, rather than on tissue specificity. Furthermore, some common types of human cancer could be induced by absorption of specific nitrosamines through skin. |
| Databáze: | OpenAIRE |
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