The Theoretical Basis for Scaling-Up by the Use of the Method of Microwave Granulation
| Autor: | Ádam Zoltan Dávid, Zoltán Ács, Zoltán Benkóczy, Dávid Greskovits, Ágoston Dávid |
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| Rok vydání: | 2000 |
| Předmět: |
Permittivity
Drug Industry Drug Compounding Entropy Energy transfer Pharmaceutical Science Mineralogy Lactose Excipients Granulation X-Ray Diffraction Pharmaceutical technology Drug Discovery Technology Pharmaceutical Particle Size Microwaves Scaling Pharmacology Basis (linear algebra) Chemistry Organic Chemistry Water Experimental data Humidity Mechanics Kinetics Models Chemical Powders Calcium Citrate Microwave |
| Zdroj: | Drug Development and Industrial Pharmacy. 26:943-951 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1081/ddc-100101321 |
| Popis: | For the scaling-up achieved by the use of the method of wet microwave granulation based on calculations, there is a need for an exact mathematical description for the relationship between the dose of radiation and the resultant effect. By assessing the physical, physical-chemical, and chemical factors, we may conclude that, by the gross kinetic evaluation of the change in the enthalpy and the loss of humidity, there is a possible solution for the mathematical description of the single-step, single-pot granulation from the practical aspect of finding ways to scale-up. This paper overviews the experiments performed in a laboratory-size microwave vacuum granulator in testing two different granules with respect to composition and permittivity and presents the evaluation of the experimental data. |
| Databáze: | OpenAIRE |
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