Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice
| Autor: | Takahiro Nagatake, Junko Isoyama, Hidehiko Suzuki, Yuichi Abe, Makoto Arita, Koji Hosomi, Jun Kunisawa, Kento Sawane, Satoshi Fukumitsu, Ayu Matsunaga, Soichiro Hirata, Kazuhiko Aida, Takeshi Tomonaga, Jun Adachi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Linseed Oil Metabolite Peroxisome proliferator-activated receptor lcsh:TX341-641 Article Allergic inflammation Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anti-Allergic Agents lipid metabolism medicine Animals eosinophil nasal allergy Omega 3 fatty acid Administration Intranasal Inflammation chemistry.chemical_classification Nutrition and Dietetics omega-3 fatty acids business.industry Lipid metabolism Lipid signaling Eosinophil Rhinitis Allergic Eicosapentaenoic acid Eosinophils Mice Inbred C57BL PPAR gamma Disease Models Animal 030104 developmental biology medicine.anatomical_structure Eicosapentaenoic Acid 030228 respiratory system chemistry Immunology Female ppar business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 12, p 2868 (2019) Nutrients Volume 11 Issue 12 |
| ISSN: | 2072-6643 |
| Popis: | The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts of alpha-linolenic acid (ALA) dampened allergic rhinitis through eosinophilic production of 15-hydroxyeicosapentaenoic acid (15-HEPE), a metabolite of eicosapentaenoic acid (EPA). Lipidomic analysis revealed that 15-HEPE was particularly accumulated in the nasal passage of linseed oil-fed mice after the development of allergic rhinitis with the increasing number of eosinophils. Indeed, the conversion of EPA to 15-HEPE was mediated by the 15-lipoxygenase activity of eosinophils. Intranasal injection of 15-HEPE dampened allergic symptoms by inhibiting mast cell degranulation, which was mediated by the action of peroxisome proliferator-activated receptor gamma. These findings identify 15-HEPE as a novel EPA-derived, and eosinophil-dependent anti-allergic metabolite, and provide a preventive and therapeutic strategy against allergic rhinitis. |
| Databáze: | OpenAIRE |
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