Long-term follow-up of juvenile-onset cutaneous polyarteritis nodosa associated with streptococcal infection
| Autor: | R S Amos, S H Till |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Pathology Systemic disease Cutaneous Polyarteritis Nodosa Penicillins medicine.disease_cause Skin Diseases Antistreptolysin Rheumatology Recurrence Streptococcal Infections Necrotizing Vasculitis Medicine Humans Pharmacology (medical) Longitudinal Studies Child Lung business.industry Streptococcus Polyarteritis nodosa Vascular disease medicine.disease Dermatology Polyarteritis Nodosa medicine.anatomical_structure Female business Vasculitis Follow-Up Studies |
| Zdroj: | British journal of rheumatology. 36(8) |
| ISSN: | 0263-7103 |
| Popis: | Polyarteritis nodosa (PAN) is a multisystem inflammatory disease associated with necrotizing vasculitis of small and medium arteries. Although predominantly an adult disease, PAN is well described in children. It can occur in a systemic form with manifestations in skin, joints, heart, nervous system, gastrointestinal tract, lungs and kidneys, and a limited form in which disease is confined to the skin, muscles, joints and peripheral nerves. In either case, streptococcal infection has been implicated by a positive throat swab or a significant increase in either antistreptolysin O (ASOT) or antihyaluronidase titres. The limited form is thought to run a benign course, but little has been written about its long-term outcome. We describe two patients who developed a cutaneous vasculitis following a probable streptococcal infection. Both have run a relapsing and remitting course with significant elevations of ASOT and in one, at least, prophylactic penicillin has had a strikingly beneficial effect. In both patients, the disease seems to have receded during childhood, only to recur, retaining its original form, in adult life. Their current ages are 22 and 19 yr, respectively. |
| Databáze: | OpenAIRE |
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