Exuberant complex metaplastic carcinoma of the breast with sox2 expression: covering the full spectrum of ductal neoplasia of the breast

Autor:	Ana Carrió, Leonardo Rodriguez-Carunchio, Ana Ruiz, Pedro L. Fernández, Adela Saco, Amaia Sagasta, Reynaldo Falcón-Escobedo, Ramón Rull
Přispěvatelé:	Universitat de Barcelona
Předmět:	Cell type Pathology medicine.medical_specialty Oncologia Metaplastic carcinoma Not Otherwise Specified Mesenchymal stem cell Ductal carcinoma Biology medicine.disease Pathology and Forensic Medicine Squamous carcinoma Càncer de mama Breast cancer SOX2 Oncology medicine Immunohistochemistry Tumors
Zdroj:	Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona
Popis:	We report a unusual case of a 45-year-old woman with a massive metaplastic carcinoma of the breast with a complex admixture of components including giant pleomorphic cells, sarcomatoid areas, cysts with undifferentiated stratified epithelium, squamous carcinoma foci, high grade comedo-type ductal carcinoma in situ , high grade invasive carcinoma not otherwise specified (NOS) and foci with osseous differentiation. An extensive immunohistochemical panel showed expression of both epithelial and mesenchymal markers. The self-renewal marker SOX2 was expressed in different cell types, which was interpreted as a sign of the pluripotency what can in turn explain the diversity of histologic lineages present in this tumour.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48357d8ce8333b67fb16386383654c8 http://hdl.handle.net/2445/119034 Zobrazit plný text záznamu