Methylxanthines and sensorineural outcome at 14 years in children < 1501 g birthweight
| Autor: | Geoffrey W. Ford, Lex W. Doyle, Anne L. Rickards, Catherine Callanan, Peter G Davis, E. A. Kelly, Noni Davis |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Apnea medicine.drug_class Developmental Disabilities Infant Premature Diseases Cerebral palsy Child Development Theophylline Bronchodilator medicine Humans Infant Very Low Birth Weight Psychological testing Survivors Psychological Tests business.industry Cerebral Palsy Confounding Infant Newborn medicine.disease Bronchodilator Agents Anesthesia Pediatrics Perinatology and Child Health Female medicine.symptom business Complication Infant Premature Follow-Up Studies Cohort study medicine.drug |
| Zdroj: | Journal of Paediatrics and Child Health. 36:47-50 |
| ISSN: | 1440-1754 1034-4810 |
| DOI: | 10.1046/j.1440-1754.2000.00446.x |
| Popis: | Objectives: Methylxanthines, including theophylline, have been used extensively and successfully to treat apnoea in preterm infants. However, long-term consequences of such therapy are largely unknown. The aim of this study was to determine the relationship between theophylline therapy and outcome at 14 years of age in surviving preterm children of birthweight < 1501 g. Methodology: The subjects of this study were 154 consecutive survivors with birthweights < 1501 g born from 1 October 1980 to 31 March 1982; 130 (84.4%) were assessed at 14 years of age. Outcomes included motor function, psychological test scores, and growth. Results: Of the 130 children assessed, 69 (53.1%) had been exposed to theophylline; 13.0% had cerebral palsy, significantly higher than 1.6% in the 61 children not exposed to theophylline (P < 0.02). This difference remained statistically significant after adjusting for potential confounding variables including the presence of cerebroventricular haemorrhage. In contrast, after adjusting for known confounding variables, children who had received theophylline achieved higher psychological test scores. There was no association between theophylline therapy and growth. Conclusions: Theophylline therapy in the newborn period is associated with some evidence of harmful, but also helpful sensorineural effects at 14 years of age. |
| Databáze: | OpenAIRE |
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