Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression
| Autor: | Nevine M.F. El Deeb, Eman Abdelzaher |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Survivin Biology medicine.disease_cause Stem cell marker Inhibitor of Apoptosis Proteins Pathology and Forensic Medicine Nestin medicine Humans Laryngeal Neoplasms Lymph node reproductive and urinary physiology Aged Aged 80 and over Stem Cells Nodal metastasis Cell Biology Middle Aged Prognosis Laryngeal squamous cell carcinoma medicine.anatomical_structure nervous system embryonic structures Carcinoma Squamous Cell Cancer research T-stage Female Lymph Nodes biological phenomena cell phenomena and immunity Carcinogenesis Octamer Transcription Factor-3 Biomarkers |
| Zdroj: | Pathology - Research and Practice. 210:751-758 |
| ISSN: | 0344-0338 |
| Popis: | We explored the expression of the stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma (LSCC) and investigated their relationship to survivin expression. Eighty-five LSCC, and 62 non-neoplastic laryngeal tissues were analyzed immunohistochemically for the presence of OCT4, nestin and survivin. Marker expression was correlated to clinicopathological parameters. The positive detection rates of OCT4 (42.35%) and nestin (51.76%) in LSCC were higher than those of non-neoplastic mucosa (p |
| Databáze: | OpenAIRE |
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