Mean platelet volume as a possible biomarker of tumor progression in rectal cancer

Autor:	Jakub Kasprzyk, Jakub Wƚodarczyk, Adam Dziki, Ƚukasz Dziki, Marcin Wƚodarczyk, Aleksandra Sobolewska-Wƚodarczyk, Marcin Tchórzewski
Rok vydání:	2016
Předmět:	0301 basic medicine Oncology Blood Platelets Male Cancer Research medicine.medical_specialty Colorectal cancer Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Statistical significance Genetics medicine Biomarkers Tumor Humans Mean platelet volume Subclinical infection Cause of death Retrospective Studies business.industry Rectal Neoplasms Cancer General Medicine Middle Aged medicine.disease 030104 developmental biology Tumor progression 030220 oncology & carcinogenesis Disease Progression Biomarker (medicine) Female business Mean Platelet Volume
Zdroj:	Cancer biomarkers : section A of Disease markers. 17(4)
ISSN:	1875-8592
Popis:	BACKGROUND Rectal cancer is a major cause of death and an early diagnosis is crucial in decreasing mortality. Previous studies found a relation between chronic inflammation and increased risk of rectal cancer. It was shown that mean platelet volume (MPV) level might be a marker of subclinical inflammatory process in gastrointestinal tract. OBJECTIVE To determinate whether MPV could be a useful biomarker of tumor progression in the rectal cancer. METHODS One hundred and three patients with rectal cancer who underwent surgical resection of tumor were enrolled in the study. The control group consisted of 98 healthy subjects. RESULTS The association between MPV, tumor stage and clinical status were assessed. The analysis proved that pre-operative MPV level was significantly lower in rectal cancer vs. healthy individuals (10.65 ± 0.79 vs. 11.41 ± 0.76 fL; p < 0.001).Receiver-operating characteristic curve analysis suggested 11.3 as the cut-off value for MPV (sensitivity = 83%; specificity = 54%; AUC = 0.745). Surgical resection of tumor resulted in the increase of the MPV level with statistical significance (10.65 ± 0.79 fL vs. 11.21 ± 0.82 fL; p < 0.001). No relationship was found between the post-operative MPV level in cancer patients and control subjects. CONLUSION MPV level may be potentially useful and easily available biomarker for monitoring subclinical inflammation related to rectal cancer and predicting tumor progression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e480e096c42ae8dd06fed690aa8e75cd https://pubmed.ncbi.nlm.nih.gov/27802192 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.