Nanotechnology approaches for personalized treatment of multidrug resistant cancers
| Autor: | Tamara Minko, Lorna Rodriguez-Rodriguez, Vitaly P. Pozharov |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_treatment
Drug delivery system Pharmaceutical Science Nanotechnology Antineoplastic Agents Enhanced permeability and retention effect LHRH Drug Delivery Systems Cancer stem cell Neoplasms medicine Animals Humans Doxorubicin Molecular Targeted Therapy CD44 Precision Medicine Adverse effect Antibody Chemotherapy Antisense oligonucleotides Dose-Response Relationship Drug business.industry Cancer stem cells Drug Resistance Multiple Endocytosis Pump and nonpump resistance Multiple drug resistance Drug Resistance Neoplasm Passive and active targeting siRNA Personalized medicine business Peptides Camptothecin medicine.drug |
| Zdroj: | Advanced drug delivery reviews. 65(13-14) |
| ISSN: | 1872-8294 |
| Popis: | The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine. |
| Databáze: | OpenAIRE |
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