Thrombotic microangiopathy associated with use of interferon-beta
| Autor: | Angel Robles, Jorge Martínez-Ara, Teresa Olea, Maria-Luz Picazo, Rafael Selgas, Raquel Díaz-Mancebo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Thrombotic microangiopathy biology business.industry Multiple sclerosis Microangiopathy Case Report medicine.disease multiple sclerosis Gastroenterology Discontinuation Complement system Nephrology Internal medicine medicine biology.protein Antibody Adverse effect business interferon-beta thrombotic microangiopathy hemolytic uremic syndrome Kidney disease |
| Zdroj: | International Journal of Nephrology and Renovascular Disease |
| ISSN: | 1178-7058 |
| Popis: | Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. The drug is usually well tolerated, but autoimmune adverse effects, including kidney disease, have been reported. Only a few cases of hemolytic uremic syndrome-thrombotic microangiopathy associated interferon-alpha have been described so far, and even fewer with beta-interferon. We report a patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy. Complement cascade and antiphospholipid antibodies are investigated. The spectrum of renal diseases associated with interferon-beta treatment is also reviewed. |
| Databáze: | OpenAIRE |
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