DNA Processing in the Context of Noncoding Transcription
| Autor: | Isabel Schwarz, Uthra Gowthaman, Desiré García-Pichardo, Sebastian Marquardt, Yu Jin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Regulation of gene expression
0303 health sciences Transcription Genetic DNA Computational biology Biology Biochemistry Genome Chromatin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Transcription (biology) RNA polymerase Gene expression RNA Long Noncoding Molecular Biology Gene 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Gowthaman, U, García-pichardo, D, Jin, Y, Schwarz, I & Marquardt, S 2020, ' DNA Processing in the Context of Noncoding Transcription ', Trends in Biochemical Sciences, vol. 45, no. 12, pp. 1009-1021 . https://doi.org/10.1016/j.tibs.2020.07.009 Trends in Biochemical Sciences |
| ISSN: | 0968-0004 |
| DOI: | 10.1016/j.tibs.2020.07.009 |
| Popis: | RNA polymerase (RNAP)II frequently transcribes non-protein-coding DNA sequences in eukaryotic genomes into long noncoding RNA (lncRNA). Distinct molecular mechanisms linked to the position of lncRNA relative to the coding gene illustrate how noncoding transcription controls gene expression. Here, we focus on the impact of the act of lncRNA transcription on nearby functional DNA units. We review the biological significance of the act of lncRNA transcription on DNA processing, highlighting common themes, such as mediating cellular responses to environmental changes. This review combines the background of chromatin signaling with examples in several organisms to clarify when functions of ncDNA can be interpreted through the act of RNAPII transcription. |
| Databáze: | OpenAIRE |
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