Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation
| Autor: | Tjeu J. Koenders, Daan F. J. Hamstra, Floris P. J. T. Rutjes, Danny C. Lenstra, Jasmin Mecinović |
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| Rok vydání: | 2017 |
| Předmět: |
Phosphine oxide
010405 organic chemistry Reducing agent Organic Chemistry Synthetic Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis Waste product chemistry.chemical_compound chemistry Peptide bond Organic chemistry Physical and Theoretical Chemistry Phosphine |
| Zdroj: | Organic & Biomolecular Chemistry, 15, 6426-6432 Organic & Biomolecular Chemistry, 15, 30, pp. 6426-6432 |
| ISSN: | 1477-0520 |
| Popis: | Development of catalytic amide bond formation reactions has been the subject of the intensive investigations in the past decade. Herein we report an efficient organophosphorus-catalysed amidation reaction between unactivated carboxylic acids and amines. Poly(methylhydrosiloxane), a waste product of the silicon industry, is used as an inexpensive and green reducing agent for in situ reduction of phosphine oxide to phosphine. The reported method enables the synthesis of a wide range of secondary and tertiary amides in very good to excellent yields. |
| Databáze: | OpenAIRE |
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