Patterns and predictors of Staphylococcus aureus carriage during the first year of life; a longitudinal study
| Autor: | Carmit Rubin, Gili Regev-Yochay, Galia Rahav, Laurence S. Freedman, Mordechay Dolitzky, Ayala Maayan-Mezger, Ilya Novikov, Hanaa Jaber, Aylana Reiss-Mandel |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Staphylococcus aureus Longitudinal study Pediatrics medicine.medical_specialty Multivariate analysis Epidemiology 030106 microbiology First year of life medicine.disease_cause Persistence (computer science) Young Adult 03 medical and health sciences Humans Medicine Longitudinal Studies Prospective Studies Pregnancy business.industry Transmission (medicine) Infant Newborn Rectum Staphylococcal Infections medicine.disease Infectious Disease Transmission Vertical Nasal Mucosa 030104 developmental biology Carriage Carrier State Vagina Female business Cohort study |
| DOI: | 10.1101/586032 |
| Popis: | Objectives’To determine the patterns ofS. aureuscarriage in the first year of life, its determinants and dynamics of transmission between mothers and infants.MethodsProspective longitudinal cohort study ofS. aureuscarriage among mothers and their infants. Monthly screenings from pregnancy/birth through the first year of the infant’s life. Medical and lifestyle data was collected. InfantS. aureuscarriage was detected by rectal and nasal swabs and maternal carriage by nasal swabs. Multivariate analysis and an NLMixed model were used to determine predictors of carriage andS. aureuspersistence.Results130S. aureuscarrier women and their 132 infants were included in the study. 93% of the infants acquiredS. aureussometime during the first year of life, 64% of them acquired the maternal strain, mostly (66%) during the first month of life. 70 women (52.50%) and 17 infants (14%) carriedS. aureuspersistently. Early acquisition ofS. aureuscarriage was associated with longer duration of initial carriage and was the most significant predictor ofS. aureuspersistence, while day-care center attendance was negatively associated with persistent carriage.ConclusionsEarly acquisition ofS. aureus, mostly from the mother, is an important determinant of carriage persistence in infancy. |
| Databáze: | OpenAIRE |
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