CIRCULATING DOPAMINE-?-HYDROXYLASE (D?H) AND CATECHOLAMINES IN A PAEDIATRIC PHAEOCHROMOCYTOMA
| Autor: | L Ose, G Serck-Hanssen, O Sövik, T. J. Gutteberg, J R Hansen, K B Helle, K F Stöa |
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| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic nervous system Venous catheterization Physiology Adrenal Gland Neoplasms Dopamine beta-Hydroxylase Pheochromocytoma Normal values Biology Catecholamines Physiology (medical) Internal medicine medicine Dopamine β hydroxylase Humans Secretion Child Left adrenal vein Pharmacology Phenoxybenzamine Dopamine beta-monooxygenase Propranolol medicine.anatomical_structure Endocrinology Catecholamine medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 3:487-491 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1976.tb00627.x |
| Popis: | 1. Circulating catecholamines and dopamine-beta-hydroxylase (DbetaH) have been studied in a child with bilateral phaeochromocytoma. 2. Venous catheterization showed a great increase in catecholamine efflux from the left adrenal vein while DbetaH activity in the latter was only slightly elevated. 3. Circulating catecholamines fluctated greatly while DbetaH activity decreased gradually during the removal of the tumours. 4. Post-operatively, circulating catecholamines declined to normal values while DbetaH activity returned to pre-operative levels. 5. It is concluded that these tumours released circulating catecholamines independent of an exocytotic secretion of DbetaH and that the circulating DbetaH reflected the activity of the sympathetic nervous system. |
| Databáze: | OpenAIRE |
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