Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments
| Autor: | Natalia L. S. Machado, Vincent Lagente, Marcelo Eustáquio Silva, Maísa Silva, Waleska Claudia Amaral Dornas, Deoclécio Alves Chianca-Jr, Wanderson Geraldo de Lima, Andréia Carvalho Alzamora, Leonardo Máximo Cardoso |
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| Přispěvatelé: | Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universidade Federal de Ouro Preto (UFOP), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment [SDV]Life Sciences [q-bio] Blood Pressure 030204 cardiovascular system & hematology Sodium Chloride medicine.disease_cause Kidney Antioxidants Monocytes chemistry.chemical_compound 0302 clinical medicine Lymphocytes chemistry.chemical_classification Multidisciplinary biology Superoxide NF-kappa B 3. Good health [SDV] Life Sciences [q-bio] medicine.anatomical_structure Hypertension medicine.medical_specialty Drinking Behavior Oxidative phosphorylation Fructose Article Superoxide dismutase Cyclic N-Oxides 03 medical and health sciences Internal medicine medicine Humans Reactive oxygen species Superoxide Dismutase Body Weight Feeding Behavior Glucose Tolerance Test Diet Oxidative Stress 030104 developmental biology Endocrinology HEK293 Cells chemistry Gene Expression Regulation biology.protein Spin Labels Reactive Oxygen Species Oxidative stress |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.46051. ⟨10.1038/srep46051⟩ Scientific Reports, 2017, 7 (1), pp.46051. ⟨10.1038/srep46051⟩ Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep46051⟩ |
| Popis: | There is evidence that diets rich in salt or simple sugars as fructose are associated with abnormalities in blood pressure regulation. However, the mechanisms underlying pathogenesis of salt- and fructose-induced kidney damage and/or consequent hypertension yet remain largely unexplored. Here, we tested the role of oxidative state as an essential factor along with high salt and fructose treatment in causing hypertension. Fischer male rats were supplemented with a high-fructose diet (20% in water) for 20 weeks and maintained on high-salt diet (8%) associate in the last 10 weeks. Fructose-fed rats exhibited a salt-dependent hypertension accompanied by decrease in renal superoxide dismutase activity, which is the first footprint of antioxidant inactivation by reactive oxygen species (ROS). Metabolic changes and the hypertensive effect of the combined fructose-salt diet (20 weeks) were markedly reversed by a superoxide scavenger, Tempol (10 mg/kg, gavage); moreover, Tempol (50 mM) potentially reduced ROS production and abolished nuclear factor-kappa B (NF-κB) activation in human embryonic kidney HEK293 cells incubated with L-fructose (30 mM) and NaCl (500 mosmol/kg added). Taken together, our data suggested a possible role of oxygen radicals and ROS-induced activation of NF-κB in the fructose- and salt-induced hypertension associated with the progression of the renal disease. |
| Databáze: | OpenAIRE |
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