'Pure' diastolic dysfunction is associated with long-axis systolic dysfunction. Implications for the diagnosis and classification of heart failure
| Autor: | Ann C. Tweddel, Eleftherios Nicolaides, Alan G. Fraser, Dragos Vinereanu |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Systole Diastole Ventricular Dysfunction Left Tissue Doppler echocardiography Internal medicine Medicine Humans Heart Failure Ejection fraction E/A ratio business.industry Diastolic heart failure Middle Aged medicine.disease Pulse pressure medicine.anatomical_structure Cross-Sectional Studies Ventricle Heart failure Cardiology Disease Progression Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | European journal of heart failure. 7(5) |
| ISSN: | 1388-9842 |
| Popis: | Aims To investigate regional systolic function of the left ventricle, to test the hypothesis that “pure” diastolic dysfunction (impaired global diastolic filling, with a preserved ejection fraction ≥50%) is associated with longitudinal systolic dysfunction. Methods and results One hundred thirty subjects (31 patients with asymptomatic diastolic dysfunction, 30 with diastolic heart failure, 30 with systolic heart failure; and 39 age-matched normal volunteers) were studied by conventional and tissue Doppler echocardiography. Global diastolic function was assessed using the flow propagation velocity, and by estimating left ventricular filling pressure from the ratio of transmitral E and mitral annular ETDE velocities (E/ETDE); and global systolic function by measurement of ejection fraction. Radial and longitudinal functions were assessed separately from posterior wall and mitral annular velocities. Global and radial systolic function were similar in patients with “pure” diastolic dysfunction and normal subjects, but patients with either asymptomatic diastolic dysfunction or diastolic heart failure had impaired longitudinal systolic function (mean velocities: 8.0±1.2 and 7.7±1.5 cm/s, respectively, versus 10.1±1.5 cm/s in controls; p |
| Databáze: | OpenAIRE |
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