Authentication Analysis of MT-4 Cells Distributed by the National Institutes of Health AIDS Reagent Program
| Autor: | Krista A. Delviks-Frankenberry, David A Scheiblin, Eric O. Freed, Christine Happel, Melissa V. Fernandez, Vinay K. Pathak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
T-Lymphocytes
Immunology Mutant Biology Gp41 Virus Replication Microbiology Cell Line Acquired immunodeficiency syndrome (AIDS) Virology medicine Humans Permissive Acquired Immunodeficiency Syndrome Human T-lymphotropic virus 1 virus diseases Gene Products tax medicine.disease HIV Envelope Protein gp41 United States Str profiling National Institutes of Health (U.S.) Insect Science Reagent Commentary HIV-1 Microsatellite Repeats |
| Zdroj: | J Virol |
| Popis: | The MT-4 human T-cell line expresses HTLV-1 Tax and is permissive for replication of an HIV-1 gp41 mutant lacking the cytoplasmic tail. MT-4 cells (lot 150048), distributed by the NIH AIDS Reagent Program (NIH-ARP), were found to be Tax deficient and unable to host replication of the gp41-truncated HIV-1 mutant. These findings, together with short tandem repeat profiling, established that lot 150048 are not bona fide MT-4 cells. |
| Databáze: | OpenAIRE |
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