Feasibility study of a prototype extended‐wear insulin infusion set in adults with type 1 diabetes

Autor: Jasmin R. Kastner, Nisha Venkatesh, Katie Brown, Douglas B. Muchmore, Elif Ekinci, Spiros Fourlanos, Jeffrey I Joseph, Miami Shafeeq, Leon Shi, Poul Strange, Paul J. Strasma, David N. O'Neal
Rok vydání: 2022
Předmět:
Zdroj: Diabetes, Obesity and Metabolism. 24:1143-1149
ISSN: 1463-1326
1462-8902
Popis: To assess the feasibility of a prototype insulin infusion set (IIS) for extended wear in adults with type 1 diabetes.The prototype Capillary Biomedical investigational extended-wear IIS (CBX IIS) incorporates a soft, flexible, reinforced kink-resistant angled nylon-derivative cannula with one distal and three proximal ports to optimize insulin delivery. Twenty adult participants with type 1 diabetes established on insulin pump therapy used the CBX IIS for two 7-day test periods while wearing a Dexcom G5 continuous glucose monitor.Participants were able to wear the CBX IIS for an average of 6.6 ± 1.4 days. Eighty-eight percent (36 of 41) of sets were worn for 7 days. No serious adverse events were reported. Five infusion sets failed prematurely because of: unresolvable hyperglycaemia (three); hyperglycaemia with elevated ketones (one); or infection (one). Median time in range (3.9-10.0 mmol/L) was 62% (54-76). Average glucose levels per day of infusion set wear showed a statistically significant increase over time (p .001).Our preliminary observations confirm the tolerability of the prototype CBX IIS for extended wear, albeit with a deterioration in glucose control after the third day.
Databáze: OpenAIRE
Externí odkaz: