Ovarian and Circulating Inhibin Levels in Immature Female Rats Treated with Gonadotropin and after Castration*
| Autor: | Victor W. K. Lee, Julie McMASTER, Lorraine Leversha, Helen Quigg |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
endocrine system
medicine.medical_specialty Time Factors endocrine system diseases Gonadotropins Equine medicine.drug_class Ovary Andrology chemistry.chemical_compound Endocrinology Inhibin activity Internal medicine medicine Animals Inhibins Castration reproductive and urinary physiology business.industry Rats Inbred Strains Luteinizing Hormone female genital diseases and pregnancy complications Peripheral blood Rats medicine.anatomical_structure chemistry Female Follicle Stimulating Hormone Gonadotropin Equine Gonadotropins business Gonadotropins hormones hormone substitutes and hormone antagonists After treatment |
| Zdroj: | Endocrinology. 111:1849-1854 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-111-6-1849 |
| Popis: | The effects of gonadotropin (FSH, LH, and PMSG) treatment and castration on ovarian and circulating levels of inhibin in immature female rats has been investigated. PMSG (20 IU) induced a progressive increase in the concentration of inhibin in both the ovaries and peripheral blood. The circulating levels of inhibin were significantly elevated 6 h after treatment and were associated with reduced levels of FSH. Similar inverse relationships between inhibin and FSH were also observed 24 h and 64 h after PMSG injection. Mean potencies of inhibin activity in the peripheral blood were 4.9, 58, and 452 U/ml at 6, 24, and 64 h, respectively, and were accompanied by similarly elevated levels in the ovary. In contrast to PMSGprimed rats, where a gradual rise in circulating inhibin levels was observed, ovine FSH (2 μg) treatment induced a prompt increase in inhibin within 6 h, reaching values of 16.7 U/ml and returning to baseline levels by 24 h. The prompt rise of inhibin in response to FSH was also dose related. I... |
| Databáze: | OpenAIRE |
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