The Rhesus monkey as a model for testing the immunological effects of space flight
| Autor: | E.S. Miller, L. Schaffar, C. Peres, Gerald Sonnenfeld, D.A. Schmitt |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Atmospheric Science Surface Immunoglobulin medicine.drug_class CD8 Antigens Aerospace Engineering Receptors Antigen B-Cell Biology Cross Reactions Monoclonal antibody Interferon-gamma Immune system Antigen Immunity medicine Leukocytes Animals Lymph node Immunity Cellular Weightlessness Histocompatibility Antigens Class II Interleukin Astronomy and Astrophysics Space Flight Macaca mulatta Respiratory burst Geophysics medicine.anatomical_structure Space and Planetary Science Research Design Immunology Antibody Formation Antigens Surface CD4 Antigens General Earth and Planetary Sciences Lymph Nodes |
| Zdroj: | Advances in space research : the official journal of the Committee on Space Research (COSPAR). 14(8) |
| ISSN: | 0273-1177 |
| Popis: | The Rhesus monkey has been proposed as a model for the effects of space flight on immunity. In order to determine the feasibility of the use of the Rhesus monkey as a model, we studied the use of Rhesus monkey cells for immunological procedures that have been shown to be affected by space flight in both rodents and humans. We have shown that both lymph node cells and peripheral blood leukocytes can be stained with monoclonal antibodies to detect the following surface markers: CD4, CD-8, Ia and surface immunoglobulin. Also, the level of Ia antigen expression was increased by treatment of the cells with human interferon-gamma. In addition, cells were induced to produce interferons and interleukins. Isolated neutrophils also demonstrated increased oxidative burst. These data indicate that the Rhesus monkey will be a useful model for space flight studies of immunity. |
| Databáze: | OpenAIRE |
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