Epidemiology and clinical course of COVID-19 in Shanghai, China
| Autor: | Lie Xu, Jun Wu, Fang Zheng, Fei Shan, Danfeng Sun, Xueyun Wu, Shenyang Li, Li Liu, Yuyi Zhang, Yinzhong Shen, Hongzhou Lu, Yun Ling, Jun Chen, Tongyu Zhu, Qingnian Xu, Zhigang Song, Jianliang Zhang, Qin Huang, Tao Li, Yuxin Shi, Zhiping Qian, Zhaoqin Zhu, Feng Li, Joshua B. Mendelsohn |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Pediatrics Time Factors medicine.medical_treatment Oxygen therapy Case fatality rate Epidemiology Drug Discovery Medicine Health Status Indicators Young adult clinical characteristics Aged 80 and over Transmission (medicine) General Medicine Articles Middle Aged Virus Shedding Infectious Diseases Treatment Outcome epidemiology Female Coronavirus Infections Research Article Adult medicine.medical_specialty viral shedding China Adolescent 030106 microbiology Immunology clinical course Pneumonia Viral Microbiology 03 medical and health sciences Young Adult Virology Humans Pandemics Aged Retrospective Studies business.industry Outbreak COVID-19 Retrospective cohort study medicine.disease Pneumonia 030104 developmental biology Parasitology business Follow-Up Studies |
| Zdroj: | Emerging Microbes & Infections article-version (VoR) Version of Record EMERGING MICROBES & INFECTIONS |
| ISSN: | 2222-1751 |
| Popis: | Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai. Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from onset to first medical care, hospitalization and negative detection of nucleic acid by nasopharyngeal swab were 1, 4 and 8 days. Patients with mild disease using glucocorticoid tended to have longer viral shedding in blood and feces. At admission, 69.8% presented with lymphopenia and 38.8% had elevated D-dimers. Pneumonia was identified in 97.5% (314/322) of cases by chest CT scan. Severe-critical patients were 8% with a median time from onset to critical disease of 10.5 days. Half required oxygen therapy and 7.1% high-flow nasal oxygen. The case fatality rate was 0.92% with median time from onset to death of 16 days. Conclusion: COVID-19 cases in Shanghai were imported. Rapid identification, and effective control measures helped to contain the outbreak and prevent community transmission. |
| Databáze: | OpenAIRE |
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