Effects of fluoxetine on cellular immune response in stressed mice
| Autor: | Elena Rodrigo, José Balboa, María José Núñez, Julio Brenlla, Manuel Freire-Garabal, Mercedes González-Peteiro |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Cellular immunity Time Factors Lymphocyte Mitomycin Cell Count Biology Natural killer cell Mice Immune system Stress Physiological Internal medicine Fluoxetine medicine Animals Chronic stress Cells Cultured Analysis of Variance Immunity Cellular Mice Inbred BALB C Dose-Response Relationship Drug General Neuroscience Killer Cells Natural Dose–response relationship Disease Models Animal medicine.anatomical_structure Endocrinology Acoustic Stimulation Antidepressive Agents Second-Generation Serotonin Spleen medicine.drug T-Lymphocytes Cytotoxic |
| Zdroj: | Neuroscience letters. 396(3) |
| ISSN: | 0304-3940 |
| Popis: | We studied the effects of fluoxetine, a non-tricyclic antidepressant drug that selectively inhibits re-uptake of serotonin by presinaptic neurons in the brain, on cellular immune responses in mice exposed to a chronic auditory stressor. The natural killer (NK) cell activity was reduced after 4, 8, 12, 16 and 20 days of stress exposure with a partial recovery on days 16 and 20. Daily treatment with fluoxetine partially reversed these adverse effects of stress in a dose-dependent manner. Significant differences appeared when fluoxetine was administered at 2 mg/kg and maximum effect was reached at doses of 5 mg/kg. The capacity of T cells to generate cytotoxic T-lymphocytes (CTL) in mixed lymphocyte cultures and in vivo was reduced after 4 days of stress application and this effect was partially reduced when mice were injected with 5 mg/kg of fluoxetine. Nevertheless, in our experiments, fluoxetine did not significantly affect the cellular immunity in unstressed mice. In conclusion, fluoxetine seems to partially recover the adverse effects of chronic stress on cellular immune response. |
| Databáze: | OpenAIRE |
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