Impaired off-line memory consolidation in depression
| Autor: | Axel Steiger, Michael Kluge, Lisa Genzel, Martin Dresler, Petra Schüssler |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Aging Time Factors Neuropsychological Tests Procedural memory Young Adult Pharmacotherapy Memory Humans Learning Pharmacology (medical) Young adult Biological Psychiatry Depression (differential diagnoses) Aged Pharmacology Depressive Disorder Major Memory Disorders Sex Characteristics Middle Aged Antidepressive Agents Psychiatry and Mental health Neurology Practice Psychological Anesthesia Finger tapping Antidepressant Female Memory consolidation Neurology (clinical) Sleep Psychology Psychomotor Performance Sex characteristics |
| Zdroj: | European Neuropsychopharmacology. 20:553-561 |
| ISSN: | 0924-977X |
| Popis: | Sleep is critically involved in the consolidation of procedural memory. In major depression (MD) and during antidepressant pharmacotherapy, changes in sleep EEG are well documented. Here, we test if off-line motor memory consolidation is impaired in MD. 50 medicated patients with an acute episode of MD, 50 normal controls and 12 patients with a remitted episode of MD were assessed using a sequential finger tapping task before and after a night of sleep. Although depressed patients and control subjects did not differ in practice-dependent learning, healthy subjects showed markedly overnight improvements in tapping performance of 18% while patients failed to show any improvement. This pattern became even more striking when the subjects were divided by an age threshold of 30years: In the 30+yrs group the healthy subjects showed 16% overnight increase in motor performance, whereas the patients showed -10% overnight decrease. In contrast, patients and controls in the |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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