Directional dominance on stature and cognition in diverse human populations
Autor: | Joshi, P.K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., Jackson, A.U., Schurmann, C., Smith, A.V., Zhang, W., Okada, Y., Stančáková, A., Faul, J.D., Zhao, W., Bartz, T.M., Concas, M.P., Franceschini, N., Enroth, S., Vitart, V., Trompet, S., Guo, X., Chasman, D.I., O'Connel, J.R., Corre, T., Nongmaithem, S.S., Chen, Y., Mangino, M., Ruggiero, D., Traglia, M., Farmaki, A.E., Kacprowski, T., Bjonnes, A., van der Spek, A., Wu, Y., Giri, A.K., Yanek, L.R., Wang, L., Hofer, E., Rietveld, C.A., McLeod, O., Cornelis, M.C., Pattaro, C., Verweij, N., Baumbach, C., Abdellaoui, A., Warren, H.R., Vuckovic, D., Mei, H., Bouchard, C., Perry, J.R., Cappellani, S., Mirza, S.S., Benton, M.C., Broeckel, U., Medland, S.E., Lind, P.A., Malerba, G., Drong, A., Yengo, L., Bielak, L.F., Zhi, D., van der Most, P.J., Shriner, D., Mägi, R., Hemani, G., Karaderi, T., Wang, Z., Liu, T., Demuth, I., Zhao, J.H., Meng, W., Lataniotis, L., van der Laan, S.W., Bradfield, J.P., Wood, A.R., Bonnefond, A., Ahluwalia, T.S., Hall, L.M., Salvi, E., Yazar, S., Carstensen, L., de Haan, H.G., Abney, M., Afzal, U., Allison, M.A., Amin, N., Asselbergs, F.W., Bakker, S.J., Barr, R.G., Baumeister, S.E., Benjamin, D.J., Bergmann, S., Boerwinkle, E., Bottinger, E.P., Campbell, A., Chakravarti, A., Chan, Y., Chanock, S.J., Chen, C., Chen, Y.D., Collins, F.S., Connell, J., Correa, A., Cupples, L.A., Smith, G.D., Davies, G., Dörr, M., Ehret, G., Ellis, S.B., Feenstra, B., Feitosa, M.F., Ford, I., Fox, C.S., Frayling, T.M., Friedrich, N., Geller, F., Scotland, G., Gillham-Nasenya, I., Gottesman, O., Graff, M., Grodstein, F., Gu, C., Haley, C., Hammond, C.J., Harris, S.E., Harris, T.B., Hastie, N.D., Heard-Costa, N.L., Heikkilä, K., Hocking, L.J., Homuth, G., Hottenga, J.J., Huang, J., Huffman, J.E., Hysi, P.G., Ikram, M.A., Ingelsson, E., Joensuu, A., Johansson, Å., Jousilahti, P., Jukema, J.W., Kähönen, M., Kamatani, Y., Kanoni, S., Kerr, S.M., Khan, N.M., Koellinger, P., Koistinen, H.A., Kooner, M.K., Kubo, M., Kuusisto, J., Lahti, J., Launer, L.J., Lea, R.A., Lehne, B., Lehtimäki, T., Liewald, D.C., Lind, L., Loh, M., Lokki, M.L., London, S.J., Loomis, S.J., Loukola, A., Lu, Y., Lumley, T., Lundqvist, A., Männistö, S., Marques-Vidal, P., Masciullo, C., Matchan, A., Mathias, R.A., Matsuda, K., Meigs, J.B., Meisinger, C., Meitinger, T., Menni, C., Mentch, F.D., Mihailov, E., Milani, L., Montasser, M.E., Montgomery, G.W., Morrison, A., Myers, R.H., Nadukuru, R., Navarro, P., Nelis, M., Nieminen, M.S., Nolte, I.M., O'Connor, G.T., Ogunniyi, A., Padmanabhan, S., Palmas, W.R., Pankow, J.S., Patarcic, I., Pavani, F., Peyser, P.A., Pietilainen, K., Poulter, N., Prokopenko, I., Ralhan, S., Redmond, P., Rich, S.S., Rissanen, H., Robino, A., Rose, L.M., Rose, R., Sala, C., Salako, B., Salomaa, V., Sarin, A.P., Saxena, R., Schmidt, H., Scott, L.J., Scott, W.R., Sennblad, B., Seshadri, S., Sever, P., Shrestha, S., Smith, B.H., Smith, J.A., Soranzo, N., Sotoodehnia, N., Southam, L., Stanton, A.V., Stathopoulou, M.G., Strauch, K., Strawbridge, R.J., Suderman, M.J., Tandon, N., Tang, S.T., Taylor, K.D., Tayo, B.O., Töglhofer, A.M., Tomaszewski, M., T?ernikova N., Tuomilehto, J., Uitterlinden, A.G., Vaidya, D., van Hylckama Vlieg, A., van Setten, J., Vasankari, T., Vedantam, S., Vlachopoulou, E., Vozzi, D., Vuoksimaa, E., Waldenberger, M., Ware, E.B., Wentworth-Shields, W., Whitfield, J.B., Wild, S., Willemsen, G., Yajnik, C.S., Yao, J., Zaza, G., Zhu, X., BioBank Japan, Project, Salem, R.M., Melbye, M., Bisgaard, H., Samani, N.J., Cusi, D., Mackey, D.A., Cooper, R.S., Froguel, P., Pasterkamp, G., Grant, S.F., Hakonarson, H., Ferrucci, L., Scott, R.A., Morris, A.D., Palmer, C.N., Dedoussis, G., Deloukas, P., Bertram, L., Lindenberger, U., Berndt, S.I., Lindgren, C.M., Timpson, N.J., Tönjes, A., Munroe, P.B., Sørensen, T.I., Rotimi, C.N., Arnett, D.K., Oldehinkel, A.J., Kardia, S.L., Balkau, B., Gambaro, G., Morris, A.P., Eriksson, J.G., Wright, M.J., Martin, N.G., Hunt, S.C., Starr, J.M., Deary, I.J., Griffiths, L.R., Tiemeier, H., Pirastu, N., Kaprio, J., Wareham, N.J., Pérusse, L., Wilson, J.G., Girotto, G., Caulfield, M.J., Raitakari, O., Boomsma, D.I., Gieger, C., van der Harst, P., Hicks, A.A., Kraft, P., Sinisalo, J., Knekt, P., Johannesson, M., Magnusson, P.K., Hamsten, A., Schmidt, R., Borecki, I.B., Vartiainen, E., Becker, D.M., Bharadwaj, D., Mohlke, K.L., Boehnke, M., van Duijn, C.M., Sanghera, D.K., Teumer, A., Zeggini, E., Metspalu, A., Gasparini, P., Ulivi, S., Ober, C., Toniolo, D., Rudan, I., Porteous, D.J., Ciullo, M., Spector, T.D., Hayward, C., Dupuis, J., Loos, R.J., Wright, A.F., Chandak, G.R., Vollenweider, P., Shuldiner, A.R., Ridker, P.M., Rotter, J.I., Sattar, N., Gyllensten, U., North, K.E., Pirastu, M., Psaty, B.M., Weir, D.R., Laakso, M., Gudnason, V., Takahashi, A., Chambers, J.C., Kooner, J.S., Strachan, D.P., Campbell, H., Hirschhorn, J.N., Perola, M., Pola?ek O., Wilson, J.F. |
---|---|
Přispěvatelé: | Immunology, Medical Microbiology & Infectious Diseases, Erasmus MC other, Medical Informatics, Epidemiology, Pathology, Public Health, Ophthalmology, Internal Medicine, Cardiology, Child and Adolescent Psychiatry / Psychology, Biological Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Joshi, Peter K, Esko, Tonu, Mattsson, Hannele, Eklund, Niina, Gandin, Ilaria, Nutile, Teresa, Jackson, Anne U., Schurmann, Claudia, Smith, Albert V., Zhang, Weihua, Okada, Yukinori, Stančáková, Alena, Faul, Jessica D., Zhao, Wei, Bartz, Traci M., Concas, MARIA PINA, Franceschini, Nora, Enroth, Stefan, Vitart, Veronique, Trompet, Stella, Guo, Xiuqing, Chasman, Daniel I., O'Connel, Jeffrey R., Corre, Tanguy, Nongmaithem, Suraj S., Chen, Yuning, Mangino, Massimo, Ruggiero, Daniela, Traglia, Michela, Farmaki, Aliki Eleni, Kacprowski, Tim, Bjonnes, Andrew, Van Der Spek, Ashley, Wu, Ying, Giri, Anil K., Yanek, Lisa R., Wang, Lihua, Hofer, Edith, Rietveld, Cornelius A., Mcleod, Olga, Cornelis, Marilyn C., Pattaro, Cristian, Verweij, Niek, Baumbach, Clemen, Abdellaoui, Abdel, Warren, Helen R., Vuckovic, Dragana, Mei, Hao, Bouchard, Claude, Perry, John R. B., Cappellani, Stefania, Mirza, Saira S., Benton, Miles C., Broeckel, Ulrich, Medland, Sarah E., Lind, Penelope A., Malerba, Giovanni, Drong, Alexander, Yengo, Loic, Bielak, Lawrence F., Zhi, Degui, Van Der Most, Peter J., Shriner, Daniel, Mägi, Reedik, Hemani, Gibran, Karaderi, Tugce, Wang, Zhaoming, Liu, Tian, Demuth, Ilja, Zhao, Jing Hua, Meng, Weihua, Lataniotis, Lazaro, Van Der Laan, Sander W., Bradfield, Jonathan P., Wood, Andrew R., Bonnefond, Amelie, Ahluwalia, Tarunveer S., Hall, Leanne M., Salvi, Erika, Yazar, Seyhan, Carstensen, Lisbeth, De Haan, Hugoline G., Abney, Mark, Afzal, Uzma, Allison, Matthew A., Amin, Najaf, Asselbergs, Folkert W., Bakker, Stephan J. L., Barr, R. Graham, Baumeister, Sebastian E., Benjamin, Daniel J., Bergmann, Sven, Boerwinkle, Eric, Bottinger, Erwin P., Campbell, Archie, Chakravarti, Aravinda, Chan, Yingleong, Chanock, Stephen J., Chen, Constance, Chen, Y. D. Ida, Collins, Francis S., Connell, John, Correa, Adolfo, Cupples, L. Adrienne, Smith, George Davey, Davies, Gail, Dörr, Marcu, Ehret, Georg, Ellis, Stephen B., Feenstra, Bjarke, Feitosa, Mary F., Ford, Ian, Fox, Caroline S., Frayling, Timothy M., Friedrich, Nele, Geller, Frank, Scotland, Generation, Gillham Nasenya, Irina, Gottesman, Omri, Graff, Misa, Grodstein, Francine, Gu, Charle, Haley, Chri, Hammond, Christopher J., Harris, Sarah E., Harris, Tamara B., Hastie, Nicholas D., Heard Costa, Nancy L., Heikkilä, Kauko, Hocking, Lynne J., Homuth, Georg, Hottenga, Jouke Jan, Huang, Jinyan, Huffman, Jennifer E., Hysi, Pirro G., Ikram, M. Arfan, Ingelsson, Erik, Joensuu, Anni, Johansson, Åsa, Jousilahti, Pekka, Jukema, J. Wouter, Kähönen, Mika, Kamatani, Yoichiro, Kanoni, Stavroula, Kerr, Shona M., Khan, Nazir M., Koellinger, Philipp, Koistinen, Heikki A., Kooner, Manraj K., Kubo, Michiaki, Kuusisto, Johanna, Lahti, Jari, Launer, Lenore J., Lea, Rodney A., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C. M., Lind, Lar, Loh, Marie, Lokki, Marja Liisa, London, Stephanie J., Loomis, Stephanie J., Loukola, Anu, Lu, Yingchang, Lumley, Thoma, Lundqvist, Annamari, Männistö, Satu, Marques Vidal, Pedro, Masciullo, Corrado, Matchan, Angela, Mathias, Rasika A., Matsuda, Koichi, Meigs, James B., Meisinger, Christa, Meitinger, Thoma, Menni, Cristina, Mentch, Frank D., Mihailov, Evelin, Milani, Lili, Montasser, May E., Montgomery, Grant W., Morrison, Alanna, Myers, Richard H., Nadukuru, Rajiv, Navarro, Pau, Nalis, Mari, Nieminen, Markku S., Nolte, Ilja M., O'Connor, George T., Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmas, Walter R., Pankow, James S., Patarcic, Inga, Pavani, Francesca, Peyser, Patricia A., Pietilainen, Kirsi, Poulter, Neil, Prokopenko, Inga, Ralhan, Sarju, Redmond, Paul, Rich, Stephen S., Rissanen, Harri, Robino, Antonietta, Rose, Lynda M., Rose, Richard, Sala, Cinzia, Salako, Babatunde, Salomaa, Veikko, Sarin, Antti Pekka, Saxena, Richa, Schmidt, Helena, Scott, Laura J., Scott, William R., Sennblad, Bengt, Seshadri, Sudha, Sever, Peter, Shrestha, Smeeta, Smith, Blair H., Smith, Jennifer A., Soranzo, Nicole, Sotoodehnia, Nona, Southam, Lorraine, Stanton, Alice V., Stathopoulou, Maria G., Strauch, Konstantin, Strawbridge, Rona J., Suderman, Matthew J., Tandon, Nikhil, Tang, Sian Tsun, Taylor, Kent D., Tayo, Bamidele O., Töglhofer, Anna Maria, Tomaszewski, Maciej, Tšernikova, Natalia, Tuomilehto, Jaakko, Uitterlinden, Andre G., Vaidya, Dhananjay, Van Hylckama Vlieg, Astrid, Van Setten, Jessica, Vasankari, Tuula, Vedantam, Sailaja, Vlachopoulou, Efthymia, Vozzi, Diego, Vuoksimaa, Eero, Waldenberger, Melanie, Ware, Erin B., Wentworth Shields, William, Whitfield, John B., Wild, Sarah, Willemsen, Gonneke, Yajnik, Chittaranjan S., Yao, Jie, Zaza, Gianluigi, Zhu, Xiaofeng, Salem, Rany M., Melbye, Mad, Bisgaard, Han, Samani, Nilesh J., Cusi, Daniele, Mackey, David A., Cooper, Richard S., Froguel, Philippe, Pasterkamp, Gerard, Grant, Struan F. A., Hakonarson, Hakon, Ferrucci, Luigi, Scott, Robert A., Morris, Andrew D., Palmer, Colin N. A., Dedoussis, George, Deloukas, Pano, Bertram, Lar, Lindenberger, Ulman, Berndt, Sonja I., Lindgren, Cecilia M., Timpson, Nicholas J., Tönjes, Anke, Munroe, Patricia B., Sørensen, Thorkild I. A., Rotimi, Charles N., Arnett, Donna K., Oldehinkel, Albertine J., Kardia, Sharon L. R., Balkau, Beverley, Gambaro, Giovanni, Morris, Andrew P., Eriksson, Johan G., Wright, Margie J., Martin, Nicholas G., Hunt, Steven C., Starr, John M., Deary, Ian J., Griffiths, Lyn R., Tiemeier, Henning, Pirastu, Nicola, Kaprio, Jaakko, Wareham, Nicholas J., Pérusse, Loui, Wilson, James G., Girotto, Giorgia, Caulfield, Mark J., Raitakari, Olli, Boomsma, Dorret I., Gieger, Christian, Van Der Harst, Pim, Hicks, Andrew A., Kraft, Peter, Sinisalo, Juha, Knekt, Paul, Johannesson, Magnu, Magnusson, Patrik K. E., Hamsten, Ander, Schmidt, Reinhold, Borecki, Ingrid B., Vartiainen, Erkki, Becker, Diane M., Bharadwaj, Dwaipayan, Mohlke, Karen L., Boehnke, Michael, Van Duijn, Cornelia M., Sanghera, Dharambir K., Teumer, Alexander, Zeggini, Eleftheria, Metspalu, Andre, Gasparini, Paolo, Ulivi, Sheila, Ober, Carole, Toniolo, Daniela, Rudan, Igor, Porteous, David J., Ciullo, Marina, Spector, Tim D., Hayward, Caroline, Dupuis, Josée, Loos, Ruth J. F., Wright, Alan F., Chandak, Giriraj R., Vollenweider, Peter, Shuldiner, Alan R., Ridker, Paul M., Rotter, Jerome I., Sattar, Naveed, Gyllensten, Ulf, North, Kari E., Pirastu, Mario, Psaty, Bruce M., Weir, David R., Laakso, Markku, Gudnason, Vilmundur, Takahashi, Atsushi, Chambers, John C., Kooner, Jaspal S., Strachan, David P., Campbell, Harry, Hirschhorn, Joel N., Perola, Marku, Polašek, Ozren, Wilson, James F., Imperial College Healthcare NHS Trust- BRC Funding, National Institute for Health Research, BioBank Japan, Project, The BioBank Japan Project, Ehret, Georg Benedikt, Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Life Course Epidemiology (LCE), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Cardiovascular Centre (CVC) |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Male
Netherlands Twin Register (NTR) Blood Pressure BLOOD-PRESSURE INTELLIGENCE Runs of Homozygosity DISEASE Homozygosity Cohort Studies Cognition Forced Expiratory Volume GENETIC-VARIANTS Inbreeding depression Settore MED/14 - NEFROLOGIA Inbreeding Inbreeding Evolutionary genetics Quantitative trait loci Non-U.S. Gov't Dominance (genetics) ddc:616 Genetics ARCHITECTURE Genome Multidisciplinary Body Height/genetics Research Support Non-U.S. Gov't Homozygote Confounding heterozygosity inbreeding genomics QUANTITATIVE TRAITS BioBank Japan Project Biological Evolution Multidisciplinary Sciences Cholesterol Phenotype Cholesterol LDL/genetics Trait Science & Technology - Other Topics Educational Status Female Lung Volume Measurements Human INBREEDING DEPRESSION Quantitative trait loci Blood Pressure/genetics General Science & Technology Forced Expiratory Volume/genetics Lung Volume Measurement Quantitative trait locus Biology Research Support Evolutionary genetics Article LDL SDG 3 - Good Health and Well-being MD Multidisciplinary Journal Article Humans Genetic association Science & Technology Genome Human ta1184 PATHWAYS Cholesterol LDL Body Height Educational Statu ASSOCIATION ANALYSIS Evolutionary biology Genome Human/genetics ta1181 Cohort Studie Meta-Analysis |
Zdroj: | Nature Nature, 523(7561), 459-462. Nature Publishing Group Nature (Lond.) 523 (2015): 459–462. doi:10.1038/nature14618 info:cnr-pdr/source/autori:Joshi P.K.; Esko T.; Mattsson H.; Eklund N.; Gandin I.; Nutile T.; Jackson A.U.; Schurmann C.; Smith A.V.; Zhang W.; Okada Y.; Stancakova A.; Faul J.D.; Zhao W.; Bartz T.M.; Concas M.P.; Franceschini N.; Enroth S.; Vitart V.; Trompet S.; Guo X.; Chasman D.I.; O'Connel J.R.; Corre T.; Nongmaithem S.S.; Chen Y.; Mangino M.; Ruggiero D.; Traglia M.; Farmaki A.-E.; Kacprowski T.; Bjonnes A.; Van Der Spek A.; Wu Y.; Giri A.K.; Yanek L.R.; Wang L.; Hofer E.; Rietveld C.A.; McLeod O.; Cornelis M.C.; Pattaro C.; Verweij N.; Baumbach C.; Abdellaoui A.; Warren H.R.; Vuckovic D.; Mei H.; Bouchard C.; Perry J.R.B.; Cappellani S.; Mirza S.S.; Benton M.C.; Broeckel U.; Medland S.E.; Lind P.A.; Malerba G.; Drong A.; Yengo L.; Bielak L.F.; Zhi D.; Van Der Most P.J.; Shriner D.; Magi R.; Hemani G.; Karaderi T.; Wang Z.; Liu T.; Demuth I.; Zhao J.H.; Meng W.; Lataniotis L.; Van Der Laan S.W.; Bradfield J.P.; Wood A.R.; Bonnefond A.; Ahluwalia T.S.; Hall L.M.; Salvi E.; Yazar S.; Carstensen L.; De Haan H.G.; Abney M.; Afzal U.; Allison M.A.; Amin N.; Asselbergs F.W.; Bakker S.J.L.; Barr R.G.; Baumeister S.E.; Benjamin D.J.; Bergmann S.; Boerwinkle E.; Bottinger E.P.; Campbell A.; Chakravarti A.; Chan Y.; Chanock S.J.; Chen C.; Chen Y.-D.I.; Collins F.S.; Connell J.; Correa A.; Cupples L.A.; Smith G.D.; Davies G.; Dorr M.; Ehret G.; Ellis S.B.; Feenstra B.; Feitosa M.F.; Ford I.; Fox C.S.; Frayling T.M.; Friedrich N.; Geller F.; Scotland G.; Gillham-Nasenya I.; Gottesman O.; Graff M.; Grodstein F.; Gu C.; Haley C.; Hammond C.J.; Harris S.E.; Harris T.B.; Hastie N.D.; Heard-Costa N.L.; Heikkila K.; Hocking L.J.; Homuth G.; Hottenga J.-J.; Huang J.; Huffman J.E.; Hysi P.G.; Ikram M.A.; Ingelsson E.; Joensuu A.; Johansson A.; Jousilahti P.; Jukema J.W.; Kahonen M.; Kamatani Y.; Kanoni S.; Kerr S.M.; Khan N.M.; Koellinger P.; Koistinen H.A.; Kooner M.K.; Kubo M.; Kuusisto J.; Lahti J.; Launer L.J.; Lea R.A.; Lehne B.; Lehtimaki T.; Liewald D.C.M.; Lind L.; Loh M.; Lokki M.-L.; London S.J.; Loomis S.J.; Loukola A.; Lu Y.; Lumley T.; Lundqvist A.; Mannisto S.; Marques-Vidal P.; Masciullo C.; Matchan A.; Mathias R.A.; Matsuda K.; Meigs J.B.; Meisinger C.; Meitinger T.; Menni C.; Mentch F.D.; Mihailov E.; Milani L.; Montasser M.E.; Montgomery G.W.; Morrison A.; Myers R.H.; Nadukuru R.; Navarro P.; Nalis M.; Nieminen M.S.; Nolte I.M.; O'Connor G.T.; Ogunniyi A.; Padmanabhan S.; Palmas W.R.; Pankow J.S.; Patarcic I.; Pavani F.; Peyser P.A.; Pietilainen K.; Poulter N.; Prokopenko I.; Ralhan S.; Redmond P.; Rich S.S.; Rissanen H.; Robino A.; Rose L.M.; Rose R.; Sala C.; Salako B.; Salomaa V.; Sarin A.-P.; Saxena R.; Schmidt H.; Scott L.J.; Scott W.R.; Sennblad B.; Seshadri S.; Sever P.; Shrestha S.; Smith B.H.; Smith J.A.; Soranzo N.; Sotoodehnia N.; Southam L.; Stanton A.V.; Stathopoulou M.G.; Strauch K.; Strawbridge R.J.; Suderman M.J.; Tandon N.; Tang S.-T.; Taylor K.D.; Tayo B.O.; Toglhofer A.M.; Tomaszewski M.; Tsernikova N.; Tuomilehto J.; Uitterlinden A.G.; Vaidya D.; Van Hylckama Vlieg A.; Van Setten J.; Vasankari T.; Vedantam S.; Vlachopoulou E.; Vozzi D.; Vuoksimaa E.; Waldenberger M.; Ware E.B.; Wentworth-Shields W.; Whitfield J.B.; Wild S.; Willemsen G.; Yajnik C.S.; Yao J.; Zaza G.; Zhu X.; Salem R.M.; Melbye M.; Bisgaard H.; Samani N.J.; Cusi D.; Mackey D.A.; Cooper R.S.; Froguel P.; Pasterkamp G.; Grant S.F.A.; Hakonarson H.; Ferrucci L.; Scott R.A.; Morris A.D.; Palmer C.N.A.; Dedoussis G.; Deloukas P.; Bertram L.; Lindenberger U.; Berndt S.I.; Lindgren C.M.; Timpson N.J.; Tonjes A.; Munroe P.B.; Sorensen T.I.A.; Rotimi C.N.; Arnett D.K.; Oldehinkel A.J.; Kardia S.L.R.; Balkau B.; Gambaro G.; Morris A.P.; Eriksson J.G.; Wright M.J.; Martin N.G.; Hunt S.C.; Starr J.M.; Deary I.J.; Griffiths L.R.; Tiemeier H.; Pirastu N.; Kaprio J.; Wareham N.J.; Perusse L.; Wilson J.G.; Girotto G.; Caulfield M.J.; Raitakari O.; Boomsma D.I.; Gieger C.; Van Der Harst P.; Hicks A.A.; Kraft P.; Sinisalo J.; Knekt P.; Johannesson M.; Magnusson P.K.E.; Hamsten A.; Schmidt R.; Borecki I.B.; Vartiainen E.; Becker D.M.; Bharadwaj D.; Mohlke K.L.; Boehnke M.; Van Duijn C.M.; Sanghera D.K.; Teumer A.; Zeggini E.; Metspalu A.; Gasparini P.; Ulivi S.; Ober C.; Toniolo D.; Rudan I.; Porteous D.J.; Ciullo M.; Spector T.D.; Hayward C.; Dupuis J.; Loos R.J.F.; Wright A.F.; Chandak G.R.; Vollenweider P.; Shuldiner A.R.; Ridker P.M.; Rotter J.I.; Sattar N.; Gyllensten U.; North K.E.; Pirastu M.; Psaty B.M.; Weir D.R.; Laakso M.; Gudnason V.; Takahashi A.; Chambers J.C.; Kooner J.S.; Strachan D.P.; Campbell H.; Hirschhorn J.N.; Perola M.; Polasek O.; Wilson J.F./titolo:Directional dominance on stature and cognition in diverse human populations/doi:10.1038%2Fnature14618/rivista:Nature (Lond.)/anno:2015/pagina_da:459/pagina_a:462/intervallo_pagine:459–462/volume:523 Nature, vol. 523, no. 7561, pp. 459-462 Joshi, P K, Esko, T, Mattsson, H, Eklund, N, Gandin, I, Nutile, T, Jackson, A U, Schurmann, C, Smith, A V, Zhang, W, Okada, Y, Stancáková, A, Faul, J D, Zhao, W, Bartz, T M, Pina Concas, M, Franceschini, N, Enroth, S, Vitart, V, Trompet, S, Guo, X, Chasman, D I, O'Connel, J R, Corre, T, Nongmaithem, S S, Chen, Y, Mangino, M, Ruggiero, D, Traglia, M, Farmaki, A-E, Kacprowski, T, Bjonnes, A, Spek, A, Wu, Y, Giri, A K, Yanek, L R, Wang, L, Hofer, E, Rietveld, C A, McLeod, O, Cornelis, M C, Pattaro, C, Verweij, N, Baumbach, C, Abdellaoui, A, Warren, H R, Vuckovic, D, Mei, H, Bouchard, C, Perry, J R B, Cappellani, S, Mirza, S S, Benton, M C, Broeckel, U, Medland, S E, Lind, P A, Malerba, G, Drong, A, Yengo, L, Bielak, L F, Zhi, D, van der Most, P J, Shriner, D, Mägi, R, Hemani, G, Karaderi, T, Wang, Z, Liu, T, Demuth, I, Zhao, J H, Meng, W, Lataniotis, L, van der Laan, S W, Brafdfield, J P, Wood, A R, Bonnefond, A, Ahluwalia, T S, Hall, L M, Salvi, E, Yazar, S, Carstensen, L, de Haan, H G, Abney, M, Afzal, U, Allison, M A, Amin, N, Asselbergs, F W, Bakker, S J L, Barr, R G, Baumeister, S E, Benjamin, D J, Bergmann, S, Boerwinkle, E, Bottinger, E P, Campbell, A, Chakravarti, A, Chan, Y, Chanock, S J, Chen, C, Chen, Y D I, Colins, F S, Connell, J, Correa, A, Cupples, L A, Davey Smith, G, Davies, G, Dörr, M, Ehret, G, Ellis, S B, Feenstra, B, Feitosa, M F, Ford, I, Fox, C S, Frayling, T M, Friedrich, N, Geller, F, Gillham-Nasenya, I, Gottesman, O, Graff, M, Grodstein, F, Gu, C, Haley, C, Hammond, C J, Harris, S E, Harris, T B, Hastie, N D, Heard-Costa, N L, Heikkilä, K, Hocking, L J, Homuth, G, Hottenga, J J, Huang, J, Huffman, J E, Hysi, P G, Arfan Ikram, M, Ingelsson, E, Joensuu, A, Johansson, A, Jousilahti, P, Jukema, J W, Kähönen, M, Kamatani, Y, Kanoni, S, Kerr, S M, Khan, N M, Koellinger, P, Koistinen, H A, Kooner, M K, Kubo, M, Kuusisto, J, Lahti, J, Launer, L J, Lea, R A, Lehne, B, Lehtimäki, T, Liewald, D C M, Lind, L, Loh, M, Lokki, M L, London, S J, Loomis, S J, Loukola, A, Lu, Y, Lumley, T, Lundqvist, A, Männistö, S, Marques-Vidal, P, Masciullo, C, Matchan, A, Mathias, R A, Matsuda, K, Meigs, J B, Meisinger, C, Meitinger, T, Menni, C, Mentch, F D, Mihailov, E, Milani, L, Montasser, M E, Montgomery, G W, Morrison, A, Myers, R H, Nadukuru, R, Navarro, P, Nelis, M, Nieminen, M S, Nolte, I M, O'Connor, G T, Ogunniyi, A, Padmanabhan, S, Palmas, W R, Pankow, J S, Patarcic, I, Pavani, F, Peyser, P A, Pietilainen, K H, Poulter, N, Prokopenko, I, Ralhan, S, Redmond, P, Rich, S S, Rissanen, H, Robino, A, Rose, L M, Rose, R, Sala, C, Salako, B, Salomaa, V, Sarin, A-P, Saxena, R, Schmidt, H, Scott, L J, Scott, W R, Sennblad, B, Seshadri, S, Sever, P, Shrestha, S, Smith, B H, Smith, J A, Soranzo, N, Sotoodehnia, N, Southam, L, Stanton, A V, Stathopoulou, M G, Strauch, K, Strawbridge, R J, Suderman, M J, Tandon, N, Tang, S T, Taylor, K D, Tayo, B O, Töglhofer, A M, Tomaszewski, M, Tsernikova, N, Tuomilehto, J, Uitterlinden, A G, Vaidya, D, Hylckama Vlieg, A, van Setten, J, Vasankari, T, Vedantam, S, Vlachopoulou, E, Vozzi, D, Vuoksimaa, E, Waldenberger, M, Ware, E B, Wentworth-Shields, W, Whitfield, J B, Wild, S, Willemsen, G, Yajnik, C S, Yao, J, Zaza, G, Zhu, X, Salem, R M, Melbye, M, Bisgaard, H, Samani, N J, Cusi, D, Mackey, D A, Cooper, R S, Froguel, P, Pasterkamp, G, Grant, S F A, Hakonarson, H, Ferrucci, L, Scott, R A, Morris, A D, Palmer, C N A, Dedoussis, G, Deloukas, P, Bertram, L, Lindenberger, U, Berndt, S I, Lindgren, C M, Timpson, N J, Tönjes, A, Munroe, P B, Sorensen, T I A, Rotimi, C N, Arnett, D K, Oldehinkel, A J, Kardia, S L R, Balkau, B, Gambaro, G, Morris, A P, Eriksson, J G, Wright, M J, Martin, N G, Hunt, S C, Starr, J M, Deary, I J, Griffiths, L R, Tiemeier, H, Pirastu, N, Kaprio, J, Wareham, N J, Pérusse, L, Wilson, J G, Girotto, G, Caulfield, M J, Raitakari, O, Boomsma, D I, Gieger, C, van der Harst, P, Hicks, A A, Kraft, P, Sinisalo, J, Knekt, P, Johannesson, M, Magnusson, P K E, Hamsten, A, Schmidt, R, Borecki, I B, Vartiainen, E, Becker, D M, Bharadwaj, D, Mohlke, K L, Boehnke, M, van Duijn, C M, Sanghera, D K, Teumer, A, Zeggini, E, Metspalu, A, Gasparini, P, Ulivi, S, Ober, C, Toniolo, D, Rudan, I, Porteous, D J, Ciullo, M, Spector, T D, Hayward, C, Dupuis, J, Loos, R J F, Wright, A F, Chandak, G R, Vollenweider, P, Shuldiner, A R, Ridker, P M, Rotter, J I, Sattar, N, Gyllensten, U, North, K E, Pirastu, M, Psaty, B M, Weir, D R, Laakso, M, Gudnason, V, Takahashi, A, Chambers, J C, Kooner, J S, Strachan, D P, Campbell, H, Hirschhorn, J N, Perola, M, Polasek, O & Wilson, J F 2015, ' Directional dominance on stature and cognition in diverse human populations ', Nature, vol. 523, no. 7561, pp. 459-462 . https://doi.org/10.1038/nature14618 Nature, 523(7561), 459. Nature Publishing Group Nature, Vol. 523, No 7561 (2015) pp. 459-462 Joshi, P K, Esko, T, Mattsson, H, Eklund, N, Gandin, I, Nutile, T, Jackson, A U, Schurmann, C, Smith, A V, Zhang, W, Okada, Y, Stančáková, A, Faul, J D, Zhao, W, Bartz, T M, Concas, M P, Franceschini, N, Enroth, S, Vitart, V, Trompet, S, Guo, X, Chasman, D I, O'Connel, J R, Corre, T, Nongmaithem, S S, Chen, Y, Mangino, M, Ruggiero, D, Traglia, M, Farmaki, A-E, Kacprowski, T, Bjonnes, A, van der Spek, A, Wu, Y, Giri, A K, Yanek, L R, Wang, L, Hofer, E, Rietveld, C A, Lataniotis, L, Wood, A R, Hammond, C J, Harris, S E, Hysi, P G, Lehne, B, Menni, C, Wilson, J G, Spector, T D, Weir, D R, Chambers, J C 2015, ' Directional dominance on stature and cognition in diverse human populations ', NATURE, vol. 523, no. 7561, pp. 459-462 . https://doi.org/10.1038/nature14618 Nature, 523, 459-462. Nature Publishing Group Nature, 523(7561), 459-U176 |
ISSN: | 0028-0836 |
Popis: | Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10-300, 2.1 × 10-6, 2.5 × 10-10 and 1.8 × 10-10, respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. |
Databáze: | OpenAIRE |
Externí odkaz: |