Serum biomarker panel for the diagnosis of rheumatoid arthritis
| Autor: | Hee-Gyoo Kang, Mira Park, Jiyeong Lee, Sora Mun, Jieun Shin, Mi-Kyoung Lim |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Retinol-binding protein-4 lcsh:Diseases of the musculoskeletal system Vitamin D-binding protein Angiotensinogen Peptides Cyclic Sensitivity and Specificity Serology Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Serum amyloid A-4 protein Rheumatoid Factor Tandem Mass Spectrometry Internal medicine medicine Rheumatoid factor Humans Rheumatoid arthritis Autoantibodies Autoimmune disease business.industry Autoantibody medicine.disease Rheumatology 030104 developmental biology 030220 oncology & carcinogenesis Immunology Biomarker (medicine) lcsh:RC925-935 business Retinol-Binding Proteins Plasma Biomarkers Research Article Chromatography Liquid |
| Zdroj: | Arthritis Research & Therapy Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021) |
| ISSN: | 1478-6362 1478-6354 |
| Popis: | Background Rheumatoid arthritis (RA) is an autoimmune disease of inflammatory joint damage, wherein C-reactive protein and autoantibodies including rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) are rapidly elevated. These serological factors are diagnostic markers of RA; however, their sensitivity and specificity for prediction warrant improvement for an early and accurate diagnosis. Methods We aimed to identify alternative biomarkers by serum protein profiling using LC-MS/MS. We performed statistical and functional analysis of differentially expressed proteins to identify biomarker candidates complementing conventional serological tests. Results Seven biomarker candidates were verified through multiple reaction monitoring-based quantitative analysis, of which angiotensinogen (AGT), serum amyloid A-4 protein (SAA4), vitamin D-binding protein (VDBP), and retinol-binding protein-4 (RBP4) had an area under the curve over 0.8, thus distinguishing RA patients, including seronegative (RF- and anti-CCP-negative) RA patients, from healthy controls. Conclusions Therefore, among seronegative RA patients, a four-biomarker panel (AGT, SAA4, VDBP, and RBP4) can prevent false negatives and help diagnose RA accurately. |
| Databáze: | OpenAIRE |
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