In Utero Diagnosis of PHACE Syndrome by Fetal Magnetic Resonance Imaging (MRI)
| Autor: | Daniel Martín Fernández-Mayoralas, Mar Jiménez-de-la-Peña, Nuria Muñoz-Jareño, Ana Laura Fernández-Perrone, Manuel Recio-Rodríguez, Alberto Fernández-Jaén |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Cerebral arteries Gravidity Prenatal diagnosis Microphthalmia Aortic Coarctation Pregnancy Cerebellum Prenatal Diagnosis medicine.artery Cerebellar hemisphere medicine Humans Eye Abnormalities business.industry Neurocutaneous Syndromes medicine.disease Magnetic Resonance Imaging Hypoplasia Posterior inferior cerebellar artery Dysplasia In utero Pediatrics Perinatology and Child Health Female Neurology (clinical) business |
| Zdroj: | Journal of Child Neurology. 29:118-121 |
| ISSN: | 1708-8283 0883-0738 |
| Popis: | The acronym PHACE describes the association of facial hemangioma with anomalies of the posterior fossa, cerebral arteries, and cardiovascular and ocular alterations. This study presents a case of diagnostic suspicion based on fetal MRI. We report the case of a pregnant woman whose 26-week MRI revealed a female fetus with hypoplasia of the right cerebellar hemisphere and right microphthalmia, leading to the suspicion of PHACE syndrome. The diagnosis was confirmed at birth, together with other criteria: facial hemangioma, absent posterior inferior cerebellar artery, and dysplasia of the right internal carotid artery. To our knowledge, this is the first live case described prenatally with both ocular and cerebellar findings on fetal MRI that suggest PHACE syndrome. The prenatal presence of 2 PHACE criteria led to the suspicion of this syndrome, and prenatal diagnostic criteria might be developed to improve information regarding the prognosis of cerebellar malformations. |
| Databáze: | OpenAIRE |
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