Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients
| Autor: | René Koopman, Ralph J. F. Manders, Brechje Kaastra, Jos H. C. H. Stegen, Wim H. M. Saris, Hans A. Keizer, L.J.C. van Loon, Annemie P. Gijsen |
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| Přispěvatelé: | Humane Biologie, Bewegingswetenschappen, RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Lipolysis Endocrinology Diabetes and Metabolism medicine.medical_treatment Palmitates Adipose tissue White adipose tissue Fatty Acids Nonesterified Biology Body Mass Index chemistry.chemical_compound Internal medicine Diabetes mellitus Internal Medicine medicine Humans Insulin Intramyocellular lipids Muscle Skeletal Aged Hypolipidemic Agents Glycogen Skeletal muscle Middle Aged medicine.disease Diet Kinetics Endocrinology medicine.anatomical_structure Adipose Tissue Breath Tests Diabetes Mellitus Type 2 chemistry Pyrazines Body Composition Exercise Test Female Energy Metabolism Oxidation-Reduction Algorithms |
| Zdroj: | Diabetologia, 48(10), 2097-2107. Springer, Cham |
| ISSN: | 0012-186X |
| Popis: | AIMS/HYPOTHESIS: In the present study, we investigated the consequences of adipose tissue lipolytic inhibition on skeletal muscle substrate use in type 2 diabetic patients. MATERIALS AND METHODS: We studied ten type 2 diabetic patients under the following conditions: (1) at rest; (2) during 60 min of cycling exercise at 50% of maximal workload capacity and subsequent recovery. Studies were done under normal, fasting conditions (control trial: CON) and following administration of a nicotinic acid analogue (low plasma non-esterified fatty acid trial: LFA). Continuous [U-(13)C]palmitate and [6,6 -(2)H(2)]glucose infusions were applied to quantify plasma NEFA and glucose oxidation rates, and to estimate intramuscular triacylglycerol (IMTG) and glycogen use. Muscle biopsies were collected before and after exercise to determine net changes in lipid and glycogen content specific to muscle fibre type. RESULTS: Following administration of the nicotinic acid analogue (Acipimox), the plasma NEFA rate of appearance was effectively reduced, resulting in lower NEFA concentrations in the LFA trial (p |
| Databáze: | OpenAIRE |
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